Absorbable and adhesive hemostatic sponge and preparation method thereof

A hemostatic sponge and adhesion technology, which is applied in the field of absorbable and adhesive hemostatic sponge and its preparation, can solve the problems of offset wound position, hemostatic material falling off, hemostatic failure, etc., and achieve appropriate mechanical strength, good safety, and low residual volume Effect

Active Publication Date: 2021-04-16
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gelatin sponge is pressed against the tissue during the process of hemostasis, and the binding force between it and the wound is very weak. It mainly relies on external gauze for pressing, or relies on the gravity of the gelatin sponge itself to absorb blood and swell to attach to the wound. When the body moves , the hemostatic material is likely to fall off or shift the position of the wound, resulting in hemostasis failure

Method used

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  • Absorbable and adhesive hemostatic sponge and preparation method thereof
  • Absorbable and adhesive hemostatic sponge and preparation method thereof
  • Absorbable and adhesive hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] An absorbable and adhesive hemostatic sponge is prepared by the following steps:

[0038] S1. Take 20g of existing gelatin, add 80ml of water, put it in an oven at 50°C until the gelatin is completely dissolved, and prepare an aqueous solution of gelatin with a mass concentration of 20% for later use;

[0039] S2. Place the gelatin solution completely dissolved in S1 in a large beaker, stir mechanically, and pass N 2 Foaming, the speed is 1000r / min, the nitrogen flow is controlled at 0.1cm 3 / s, and measure 0.2g TG enzyme solution and dissolve it in 10ml water, then drop TG enzyme solution into the gelatin solution to crosslink the gelatin, wherein the dropping rate of TG enzyme solution is 0.25mL / s;

[0040] S3. Place the cross-linked gelatin solution in S2 in an ice bath and continue to stir for 30 minutes. After the temperature of the system is stable, stop stirring to obtain a gelatinous gelatin system;

[0041]S4. Measure 1.000g (5.216mmol) of water-soluble carbo...

Embodiment 2

[0045] An absorbable and adhesive hemostatic sponge is prepared by the following steps:

[0046] S1. Take 50g of existing gelatin, add 50ml of water, put it in an oven at 40°C until the gelatin is completely dissolved, and prepare a gelatin aqueous solution with a mass concentration of 50% for later use;

[0047] S2. Place the gelatin solution completely dissolved in S1 in a large beaker, stir mechanically, and pass N 2 Foaming, the speed is 1000r / min, the nitrogen flow is controlled at 1cm 3 / s, and measure 0.05g TG enzyme solution to be dissolved in 10ml water, drop TG enzyme solution in gelatin solution then gelatin is cross-linked, wherein the rate of addition of TG enzyme solution is 0.25ml / s;

[0048] S3. Place the cross-linked gelatin solution in S2 in an ice bath and continue to stir for 30 minutes. After the temperature of the system is stable, stop stirring to obtain a gelatinous gelatin system;

[0049] S4. Measure 2.500g (13.040mmol) of water-soluble carbodiimide...

Embodiment 3

[0053] An absorbable and adhesive hemostatic sponge is prepared by the following steps:

[0054] S1. Take 5g of existing gelatin, add 95ml of water, put it in an oven at 80°C until the gelatin is completely dissolved, and prepare an aqueous solution of gelatin with a mass concentration of 5% for later use;

[0055] S2. Place the gelatin solution completely dissolved in S1 in a large beaker, stir mechanically, and pass N 2 Foaming, the speed is 1000r / min, the nitrogen flow is controlled at 10cm 3 / s, and measure 0.5g TG enzyme and dissolve it in 10ml water, then drop TG enzyme solution in the gelatin solution to cross-link the gelatin, wherein the rate of addition of TG enzyme solution is 0.25ml / s;

[0056] S3. Place the cross-linked gelatin solution in S2 in an ice bath and continue to stir for 30 minutes. After the temperature of the system is stable, stop stirring to obtain a gelatinous gelatin system;

[0057] S4. Measure 0.250g (1.304mmol) of water-soluble carbodiimide (...

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Abstract

The invention provides an absorbable and adhesive hemostatic sponge and a preparation method thereof. The hemostatic sponge is made of biodegradable and absorbable gelatin, the hemostatic sponge has a microscopic porous structure, and at least one surface of the hemostatic sponge is modified with succinimide groups by soaking in EDC-NHS solution. The absorbable and adhesive hemostatic sponge of the present invention has good adhesion ability to the wound surface, can be firmly attached to the surface of the tissue, effectively prevents the hemostatic sponge from falling off or moving during the hemostasis process, and can realize effective hemostasis on the wound surface and prevent secondary bleeding, and the hemostatic sponge has a low volume swelling rate and a high mass swelling rate, has a significant hemostatic effect and does not cause compression on tissues and nerves. In addition, the preparation method of the absorbable and adhesive hemostatic sponge is simple, and has good practicability and scalability.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to an absorbable and adhesive hemostatic sponge and a preparation method thereof. Background technique [0002] Gelatin sponge is a commonly used wound hemostatic material in clinical practice. Its use method is to wipe off the bleeding on the surface of the tissue, stick it on the wound surface with dry gelatin sponge, and then press it with dry gauze to stop bleeding. Due to the large specific surface area of ​​gelatin sponge, the water absorption capacity can reach more than 30 times its own volume. When the whole sponge is attached to the wound surface, it can absorb blood more than 30 times its own weight, and can be used like a cast. Blood coagulates in it. The gelatin sponge material can be absorbed by the body within 4 to 6 weeks, so it can be left in the body cavity or wound cavity. In addition, the contact of gelatin with tissue will not produce excessive sc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00
CPCA61L24/0036A61L24/104A61L2400/04
Inventor 马骋张馨之邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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