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Needles used for 3d printing, method of 3d printing a cylindrical single fiber with petal grooves

A 3D printing, single fiber technology, used in medical science, prosthesis, additive processing, etc., can solve problems such as regulating cell behavior, achieve good cell adhesion, accurate and effective design solutions, and promote cell adhesion. Effect

Active Publication Date: 2021-03-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the fibers extruded by the melt extrusion process are all slender and cylindrical, and the cells can only feel the two-dimensional planar structure, but cannot regulate the cell behavior on the three-dimensional scale.

Method used

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  • Needles used for 3d printing, method of 3d printing a cylindrical single fiber with petal grooves
  • Needles used for 3d printing, method of 3d printing a cylindrical single fiber with petal grooves
  • Needles used for 3d printing, method of 3d printing a cylindrical single fiber with petal grooves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A needle used for 3D printing, the needle structure includes a petal-shaped groove, the petal-shaped groove is composed of semicircular grooves in series, the radius of the semicircular groove is 20 μm, and the diameter of the circumscribed circle of the needle is 1000 μm, the diameter of the inscribed circle of the needle is 980 μm, and the needle 3D prints a cylindrical single fiber with petal grooves.

[0026] The length of the needles is 3000 μm. The material of the needle is stainless steel.

[0027] A method of 3D printing a cylindrical single fiber with petal grooves, using the above-mentioned needle to print the fiber. The printing material is hydroxyapatite. The pressure of the method is 0.4Mpa, and the printing temperature is room temperature.

[0028] Orthogonal hydroxyapatite scaffolds of 1 cm × 1 cm × 3 mm were printed according to the above parameters, the spacing between scaffold layers was 900 μm, and the spacing between fibers was 800 μm. After high...

Embodiment 2

[0031] A needle used for 3D printing, the needle structure includes a petal-shaped groove, the petal-shaped groove is composed of semicircular grooves in series, the radius of the semicircular groove is 20 μm, and the diameter of the circumscribed circle of the needle is 400 μm, the diameter of the inscribed circle of the needle is 380 μm, and the needle 3D prints a cylindrical single fiber with petal grooves.

[0032] The length of the needles is 2000 μm. The material of the needle is stainless steel.

[0033] A method of 3D printing a cylindrical single fiber with petal grooves, using the above-mentioned needle to print the fiber. The printing material is poly(lactic-co-glycolic acid) (PLGA). The pressure of the method is 0.2MPa, and the printing temperature is 80°C.

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Abstract

The invention discloses a needle used for 3D printing. The structure of the needle induces a petal-shaped groove. The petal-shaped groove is composed of semicircular grooves in series. The radius of the semicircular groove is 5-10 micrometers. The diameter of the circumscribed circlem of the needle is 100-1000 micrometers. The diameter of the inscribed circle of the needle is 80-980 micrometers. The needle prints a cylindrical single fiber with a petal groove in 3D mode. The invention also discloses a 3D printing method of a cylindrical single fiber with a petal groove by using the needle. Thefiber stent printed by the method has the capabilities of better promoting cell adhesion and migration, and promoting differentiation of cells to a specific direction in a more controllable way.

Description

technical field [0001] The invention belongs to the fields of 3D printing and tissue engineering, and specifically relates to a needle used for 3D printing and a method for 3D printing a cylindrical single fiber with petal grooves. Background technique [0002] The construction of animal tissues is not only the result of multicellular interaction, but also the result of the interaction and complementarity between cells and extracellular matrix. Factors such as mechanical stress on cells, intercellular adhesion, and cytokines all combine to regulate cell behavior. For example, a large number of studies have confirmed that the micro-nano structure of the extracellular matrix (such as grooves) can affect the migration and differentiation of cells. In tissue engineering, the main function of the scaffold is to simulate the extracellular matrix and provide nutrients and mechanical support for the growth of cells. There are many manufacturing methods for scaffolds. Among them, 3...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/18B33Y30/00B33Y10/00
CPCA61L27/12A61L27/18B33Y10/00B33Y30/00C08L67/04
Inventor 王迎军冀俞蓉付晓玲
Owner SOUTH CHINA UNIV OF TECH