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Method for detecting forbidden drugs with internal modified molecular tube as chemical sensor

A chemical sensor and molecular tube technology, applied in the field of drug detection, can solve the problems of time-consuming, labor-intensive, high cost, etc.

Active Publication Date: 2018-09-07
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nowadays, it is basically to detect synephrine, Procaine, phenacetin and ephedrine, these traditional methods are not only time-consuming and labor-intensive but also cost high, and are very unsuitable for sports events and judicial fields

Method used

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  • Method for detecting forbidden drugs with internal modified molecular tube as chemical sensor
  • Method for detecting forbidden drugs with internal modified molecular tube as chemical sensor
  • Method for detecting forbidden drugs with internal modified molecular tube as chemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] At 25°C, 100 μL of internally modified molecular tubes (5×10 -6 M) aqueous solution was added in the 96-well plate, and then 50 μ L of synephrine solutions of different concentrations prepared with simulated urine were added successively. The concentrations of ephedrine in each sample were 0, 15, 20, 25, 30, 40, 50 and 80 μ M, Detect with a fluorescence reader, the detection conditions are excitation wavelength 350nm, emission wavelength 403nm, repeat 12 times. The result is as follows figure 1 shown.

[0040] From figure 1 It can be seen that the detection limit of the internally modified molecular tube shown in Formula I for synephrine is 1.4 μg / mL, and the linear range is 0-50 μM.

Embodiment 2

[0042] At 25°C, 100 μL of internally modified molecular tubes (5×10 -6 M) aqueous solution was added in the 96-well plate, and then added successively 50 μ L of procaine hydrochloride solutions of different concentrations prepared with simulated urine, the concentration of each sample ephedrine was respectively 0, 15, 20, 25, 30, 40, 50 and 80 μM, detected with a fluorescence reader, the detection conditions are excitation wavelength 350nm, emission wavelength 403nm, repeated 12 times. The result is as follows figure 2 shown.

[0043] From figure 2 It can be seen that the detection limit of the internally modified molecular tube shown in Formula I for procaine hydrochloride is 0.7 μg / mL, and the linear range is 0-30 μM.

Embodiment 3

[0045] At 25°C, put 100 μL of internally modified molecular tubes (5×10 -6 M) aqueous solution was added in the 96-well plate, and then added successively 50 μ L of procaine hydrochloride solutions of different concentrations prepared with simulated urine, the concentration of each sample ephedrine was respectively 0, 15, 20, 25, 30, 40, 50 and 80 μM, detected with a fluorescence reader, the detection conditions are excitation wavelength 350nm, emission wavelength 403nm, repeated 12 times. The result is as follows image 3 shown.

[0046] From image 3 It can be seen that the detection limit of the internally modified molecular tube shown in formula II for procaine hydrochloride is 3.1 μg / mL, and the linear range is 0-80 μM.

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Abstract

The invention provides a method for detecting forbidden drugs with an internal modified molecular tube as a chemical sensor. According to the method, the internal modified molecular tube is taken as the chemical sensor, the chemical sensor and a detected sample are mixed, a mixed solution is obtained, and the fluorescence intensity of the mixed solution is tested. The method can rapidly, simply and sensitively detect four forbidden drugs including ephedrine, synephrine, phenacetin and procaine in a water-phase system. The method has very important application prospects in detection and judicial fields of stimulants in sports events.

Description

technical field [0001] The invention belongs to the field of drug detection, and relates to a method for detecting prohibited drugs by using internally modified molecular tubes as chemical sensors. Background technique [0002] The abuse of illegal drugs has become a very serious social problem. Ephedrine is not only the raw material for synthesizing methamphetamine, it is listed as a prescription drug in my country, and it is also an amphetamine-type stimulant, which is banned by athletes from the World Anti-Doping Organization, and its urine cannot exceed 10 μg / mL. Although synephrine is a natural sympathomimetic amine stimulant, it was also included in the testing items of the World Anti-Doping Organization in 2018. Procaine and phenacetin are widely used as adulterants of cocaine because of their analgesic effects and low cost. Cocaine containing adulterants may cause more serious adverse reactions after being abused. Therefore, the detection of these compounds has ver...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/643G01N2021/6439
Inventor 蒋伟马延龙王瑞兵
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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