Method for preparing infantile lung clearing and phlegm eliminating preparation

A technology for clearing the lungs and resolving phlegm, and preparations, which are applied in pharmaceutical formulas, medical preparations containing active ingredients, active ingredients of aluminum/calcium/magnesium, etc., and can solve the problems of laetrile enzyme decomposition, high loss, and poor product stability. Achieve the effects of preventing hydrolysis, increasing extraction rate and improving curative effect

Active Publication Date: 2011-09-21
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the ephedrine in the drug formula is volatile, and it loses more when it is extracted and concentrated at high temperature; the chemical property of amygdalin is unstable, it is easily destroyed by acid and alkali, and it is more likely to be decomposed by amygdalin; therefore, this method is not conducive to formulating The active ingredients of each component are enriched, the product stability is poor, and the efficacy of the drug needs to be further improved

Method used

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  • Method for preparing infantile lung clearing and phlegm eliminating preparation
  • Method for preparing infantile lung clearing and phlegm eliminating preparation
  • Method for preparing infantile lung clearing and phlegm eliminating preparation

Examples

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Embodiment 1

[0019] Prescription: Ephedra 30g, Gypsum 225g, Bitter Almond 75g, Peucedanum 75g, Scutellaria Baicalensis 75g, Perilla Seed (Fried) 75g, Tinglizi 93g, Zhuru 75g.

[0020] Preparation method: the above eight flavors, take ephedra and pulverize into coarse powder; take 2 times the amount of water, adjust to pH 3 acidic water solution, soak the ephedra coarse powder, soak for 2 days, perform percolation extraction, collect 8 times percolate , Adjust the pH to 6, filter and concentrate for later use; after the bitter almonds are broken, the enzymes are quickly inactivated with circulating steam for 40 minutes, and the bitter almonds after the enzymes are removed, add 1 times the amount of 30% ethanol, soak for 2 days, and then percolate, collect 6 times percolation liquid , Filtered and concentrated, set aside. The gypsum is boiled in water for 1 hour, then add Peucedanum, Scutellaria baicalensis, Perilla Seed (stir-fried), Zhuru, put the Tinglizi in the yarn bag, add water and cook ...

Embodiment 2

[0022] Prescription: Ephedra 40g, Gypsum 60g, Bitter Almond 90g, Peucedanum 90g, Scutellaria 90g, Perilla Seed (Fried) 90g, Tinglizi 120g, Zhuru 90g.

[0023] Preparation method: the above eight flavors, pulverize ephedra into coarse powder, add 1 times the amount of acidic aqueous solution with pH 4 to soak for 1 day, then perform percolation extraction, collect 16 times percolate, adjust pH 6, filter and concentrate for later use; bitter almond After crushing, the enzymes were quickly inactivated with circulating steam for 30 minutes, the bitter almonds after the enzymes were removed, added with 1 times of 50% ethanol, soaked for 2 days, and then percolated. The 7 times percolate was collected, filtered and concentrated for use. Gypsum was boiled in water for 1 hour and then combined with the remaining four flavors of Qianhu and other four flavors (Tinglizi Baojian). Add water to decoc 2 times, each time adding 8 times the amount of water, decocting for 1 hour, filter, concentra...

Embodiment 3

[0025] Prescription: Ephedra 20g, Gypsum 150g, Bitter almond 50g, Peucedanum 20g, Scutellaria baicalensis 60g, Perilla seed (fried) 90g, Tinglizi 60g, Zhuru 90g.

[0026] Preparation method: the above eight flavors, pulverize ephedra into coarse powder, add 3 times the amount of acidic aqueous solution with pH 3.5 to soak for 2 days, then perform percolation extraction, collect 20 times percolate, adjust pH 6, filter and concentrate for later use; crushed bitter almonds Then, the enzymes were quickly inactivated with circulating steam for 60 minutes, the bitter almonds after the enzymes were removed, added with 1 times the amount of 10% ethanol, soaked for 2 days, and then percolated, and the 3 times percolate was collected, filtered and concentrated for use. Gypsum was boiled in water for 1 hour and then combined with the remaining four flavors of Qianhu and other four flavors (Tinglizi Baojian). Add water to decoc 2 times, add 6 times the amount of water each time, decoc for 1 h...

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Abstract

The invention discloses a method for preparing an infantile lung clearing and phlegm eliminating preparation, which comprises the following steps of: a, weighing ephedra, gypsum, bitter almond, whiteflower hogfennel root, baical skullcap root, perilla fruit powder, pepperweed seed and bamboo shavings; b, soaking ephedra coarse powder in acidic aqueous solution, and percolating for extracting; c, crushing bitter almond, inactivating enzyme, and extracting by low-degree alcoholic solution; d, decocting gypsum, adding other components, extracting in water, mixing with ephedra concentrating solution and bitter almond concentrating solution, and concentrating to form extract; and e, adding an excipient and auxiliary materials, and preparing by the conventional method of preparations to obtain a pharmaceutically-acceptable preparation. By the method, the extraction rate of ephedrine and amygdalin can be improved, the curative effect of medicines can be improved, and the quality stability of products can be improved simultaneously.

Description

Technical field [0001] The invention relates to a preparation method of pharmaceutical preparations, in particular to a preparation method of a pharmaceutical preparation for clearing away heat, resolving phlegm, relieving cough and relieving asthma. technical background [0002] Xiaoer Qingfei Huatan preparations are developed on the basis of Maxing Shigan Decoction in "Treatise on Febrile Diseases" in the famous traditional Chinese medicine of my country. It is composed of ephedra, gypsum, bitter almond, cephalopectin, scutellaria, perilla (stir-fried), and Ting Lizi and Zhuru are composed of eight herbs; it has the effects of clearing heat and resolving phlegm, relieving cough and relieving asthma. It has a very good curative effect on shortness of breath, cough, phlegm, and throat noise caused by children with lung heat and cold. One of the effective prescriptions to prevent influenza A virus. At present, when preparing the preparation, the gypsum in the above eight flavors is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P11/00A61P11/10A61K33/06
Inventor 陈钟卢树杰陈浩达
Owner SHINEWAY PHARMA GRP LTD
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