Compound serving as anti-tumor medicine synergist and reversal agent

An anti-tumor drug and drug technology, applied in the field of medicine, can solve the problems of low selectivity, increased tumor cell death rate, and large dosage, and achieve the effect of enhancing tumor suppressing and killing effect, high clinical application value, and reducing dosage.
CN108524533AInactive Publication Date: 2018-09-14INST OF ZOOLOGY CHINESE ACAD OF SCI +1
1 Cites 4 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2018-09-14
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a compound serving as an anti-tumor medicine synergist and a reversal agent and belongs to the technical field of medicines. The invention provides application of an avermectinmedicine to preparation of an anti-tumor medicine and application of the avermectin medicine to preparation of the anti-tumor medicine synergist or the reversal agent. The invention also provides ananti-tumor medicine composition which comprises one or more anti-tumor medicines and one or more avermectin medicines as effective components. The avermectin medicine is avermectin, ivermectin, epiomycin, doramectin or eprinomectin, and the anti-tumor medicine is vincristine and salt thereof, daunorubicin, taxol and salt thereof or doxorubicin. The avermectin medicine can improve the sensibility of tumors to chemotherapeutic medicines and thus can be used as the anti-tumor medicine synergist; and the avermectin medicine has an excellent effect on reversing the medicine resistance of tumor cells to the anti-tumor medicine.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a compound used as a synergist and a reversal agent for antitumor drugs. Background technique

[0002] Cancer is one of the important diseases that endanger public health, and its morbidity and mortality are increasing year by year. Although there are many ways to treat cancer, chemotherapy is still a common method of treatment, but long-term chemotherapy can easily lead to multidrug resistance in patients, resulting in reduced curative effect or even failure of chemotherapy.

[0003] The mechanism of multidrug resistance in tumor cells is quite complex, and there are many influencing factors. Among them, multidrug resistance gene 1 (MDR1) plays a major role in multidrug resistance of tumor cells and is the most deeply studied. It is P-glycoprotein (P-gp), which acts as an efflux pump for macromolecular drugs or poisons that rely on ATP energy, and can expel drugs o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More