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Azelaic acid gel and its preparation method and application

A technology of azelaic acid gel and azelaic acid, which is applied in the fields of pharmaceutical formulations, aerosol delivery, active ingredients of salicylic acid, etc. It can solve the problem of low content of effective substances, heavy oily feeling of azelaic acid, and large side effects and other issues, to achieve the effect of improving the cure rate, reducing physical and psychological pain, and low cost

Active Publication Date: 2020-05-12
CHENGDU JOY YOUNG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the cream-type azelaic acid has a relatively oily feel, poor air permeability, relatively large side effects, and low active substance content

Method used

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  • Azelaic acid gel and its preparation method and application
  • Azelaic acid gel and its preparation method and application
  • Azelaic acid gel and its preparation method and application

Examples

Experimental program
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Effect test

preparation example Construction

[0035] The preparation method of azelaic acid gel of the present invention comprises the steps:

[0036] a. Uniformly disperse ZEN in 1,3-propanediol and then mix it with water to obtain solution A;

[0037] b. Uniformly disperse azelaic acid in 1,3-propanediol and heat to 65-80°C to obtain solution B;

[0038] c. Uniformly disperse salicylic acid in 1,3-propanediol to obtain solution C;

[0039] d. Mix solution A, solution B and solution C, stir and mix at 55-65° C., and then cool to room temperature to obtain azelaic acid gel.

[0040] Wherein, there is no time sequence among step a, step b and step c, and step a, step b, or step c may be performed first, or these three steps may be performed simultaneously. Just mix solution A, solution B and solution C at the end and stir well.

[0041] The present invention also provides the application of the azelaic acid gel described in the present invention in the preparation of medicines for preventing or treating acne.

[0042]T...

Embodiment 1

[0050] Prepare azelaic acid gel as follows:

[0051] a. Uniformly disperse ZEN in 1,3-propanediol and then mix it with water to obtain solution A;

[0052] b. Uniformly disperse azelaic acid in 1,3-propanediol, heat to 75°C, and stir until transparent to obtain solution B;

[0053] c. Uniformly disperse salicylic acid in 1,3-propanediol to obtain solution C;

[0054] d. Mix solution A, solution B and solution C, stir and mix at 60°C, and then cool to room temperature to obtain azelaic acid gel.

[0055] Wherein, the formula of each raw material is shown in Table 1.

[0056] Table 1

[0057]

[0058] On the basis of this formula, a certain amount of bacteria (18000cfu / g or mold 8700cfu / g liquid) is artificially introduced, and then a quantitative sample is taken to measure its antibacterial effect, and the results are shown in Table 2.

[0059] Table 2

[0060]

[0061] It can be seen from Table 2 that although no preservative is added to the system, it can still be ...

Embodiment 2～4

[0063] Azelaic acid gel was prepared according to the method described in Example 1, wherein the total amount of each raw material is shown in Table 3.

[0064] table 3

[0065]

[0066] Measure the antibacterial property of above-mentioned product, find that the product of embodiment 2~4 also has antibacterial property.

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Abstract

The invention relates to azelaic acid gel and its preparation method and application, belonging to the technical field of skin medicine. The technical problem that the present invention solves is to provide a kind of azelaic acid gel, and this azelaic acid gel is made up of the following components by weight percentage: azelaic acid 10~20%, salicylic acid 0.5~2%, ZEN 1~3%, 1,3‑propylene glycol 60~74%, the rest is water. The invention adopts specific raw materials to prepare the azelaic acid into a gel, the product is transparent and free of precipitation, can penetrate the skin well, can be used in the treatment or prevention of acne, and improves the cure rate of acne patients. Moreover, the composition is simple, antibacterial is still possible without adding preservatives, and the preparation method is simple and the cost is low.

Description

technical field [0001] The invention relates to azelaic acid gel and its preparation method and application, belonging to the technical field of skin medicine. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. It mainly occurs in adolescents and has a great psychological and social impact on adolescents, but it can often be relieved or cured naturally after puberty. The clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that are prone to occur on the face. [0003] According to the joint survey of my country Dermatology Association and my country Youth Federation, the incidence of acne in my country is on the rise year by year, and more than 80% of people have encountered acne problems in varying degrees. The incidence of severe acne accounts for more than 1 / 3 of young people. Among them, there are 294 million middle school students with acne, 133 million coll...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/20A61K31/60A61K47/32A61K47/10A61P17/10
CPCA61K47/10A61K47/32A61P17/10A61K9/0014A61K9/06A61K31/20A61K31/60A61K2300/00A61K31/194
Inventor 王广基
Owner CHENGDU JOY YOUNG BIOTECH CO LTD
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