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A method for establishing a model of quality control in the production process of traditional Chinese medicine

A production process and model building technology, applied in data processing applications, instruments, calculations, etc., can solve the problems of not considering the interaction of model parameter combinations and the number of modeling times

Active Publication Date: 2021-06-04
BEIJING UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most critical problem in applying this method is the establishment and optimization of quantitative models. However, the optimization of traditional near-infrared model parameters mostly adopts step-by-step optimization, which requires more modeling times, and does not consider the interaction between various model parameter combinations.

Method used

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  • A method for establishing a model of quality control in the production process of traditional Chinese medicine
  • A method for establishing a model of quality control in the production process of traditional Chinese medicine
  • A method for establishing a model of quality control in the production process of traditional Chinese medicine

Examples

Experimental program
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Effect test

Embodiment Construction

[0036] (1) Online collection of near-infrared spectral data of gardenia and licorice:

[0037] ①Using online near-infrared spectroscopy technology, the optical path is 2mm, and the online collection of gardenia’s optical fiber accessories has an absorption spectrum range of 800-2200nm. Each sample is scanned 32 times to obtain online near-infrared spectrum data of Gardenia, a total of 75 copies sample;

[0038]② Using online near-infrared spectroscopy technology, the optical path is 2mm, the online collection of licorice fiber optic accessories absorbs the spectrum in the range of 800-1900nm, and each sample is scanned 32 times to obtain online near-infrared spectral data of licorice, a total of 60 samples ;

[0039] (2) Determine key modeling parameters:

[0040] The key modeling parameters determined through literature and empirical analysis mainly include the sample set division ratio (K-S), the number of latent variable factors (LVs), the spectral preprocessing method (P...

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Abstract

The invention includes a method for establishing a model of quality control in the production process of traditional Chinese medicine, which is characterized in that the online near-infrared spectroscopy technology is used, two Chinese medicines, gardenia and licorice, are used as research carriers, and quality by design (QbD) is applied. Concept, with the help of the D-optimal experimental design method, the sample set division ratio (K-S), the number of latent variable factors (LVs), the spectral preprocessing method (P) and the variable screening method (V) in the near-infrared modeling process are used as experiments Factors, design and establish a near-infrared optimal model of quality control in the production process of traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to quality control of the production process of traditional Chinese medicines, and a method for establishing a quality control model of the production process of traditional Chinese medicines. Background technique [0002] The concept of quality by design (QbD) was proposed by Joseph M. Juran, a famous American quality management expert, and was first applied in the automobile industry. In 2004, the United States officially extended it to the research and development, production and commercial application of pharmaceuticals. The core idea of ​​this concept is to realize the quality control of products by designing some key quality control parameters. [0003] The quality control of the production process of traditional Chinese medicine has always been a hot topic in the pharmaceutical industry of traditional Chinese medicine. The complexity of the content of quality con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06Q10/06
CPCG06Q10/06393G06Q10/06395
Inventor 吴志生杜晨朝乔延江马丽娟黄兴国
Owner BEIJING UNIV OF CHINESE MEDICINE