A detection kit for N-terminal brain natriuretic peptide precursor

A technology for detecting kits and brain natriuretic peptides, which is applied in biological testing, measuring devices, material inspection products, etc., and can solve the problems that the latex immunoturbidimetric method is difficult to be used in conjunction with automatic biochemical analyzers

Active Publication Date: 2021-02-26
SHAOXING SHENG KANG BIOLOGICAL TECH
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Problems solved by technology

[0011] However, no ideal sensitized latex particles have been found for the detection of N-terminal BNP precursors. The present invention solves such a problem; at present, it is difficult for latex immunoturbidimetry to be used in combination with a fully automatic biochemical analyzer in clinical practice. Batch samples, and the results are mostly qualitative; the present invention solves such problems

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  • A detection kit for N-terminal brain natriuretic peptide precursor
  • A detection kit for N-terminal brain natriuretic peptide precursor
  • A detection kit for N-terminal brain natriuretic peptide precursor

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Embodiment Construction

[0114] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0115] A detection kit for N-terminal BNP precursor, comprising:

[0116] Reagent one:

[0117] Phosphate buffer (PH=6.5) 100-150mmol / L,

[0118] Preservatives 0.005%-0.06%,

[0119] Tween 20 0.5-2.0mL / L,

[0120] Polyethylene glycol 6000 25-60g / L;

[0121] Reagent 2:

[0122] Phosphate buffer (PH=8.0) 100-150mmol / L,

[0123] Disodium hydrogen phosphate 20-60g / L,

[0124] Sodium dihydrogen phosphate 2-5g / L,

[0125] Sodium chloride 10-50g / L,

[0126] Preservatives 0.005%-0.06%,

[0127] Sensitized latex particles of goat anti-human N-terminal-pre-B-type natriuretic peptide antibody 1-5ml / L;

[0128] Calibrator:

[0129] Phosphate buffer (PH=8.0) 100-150mmol / L,

[0130] Bovine serum albumin 10-50g / L,

[0131] Sodium chloride 10-50g / L,

[0132] Preservatives 0.005%-0.06%,

[0133] N-terminal-pre-B-type natriuretic peptide ant...

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Abstract

The invention discloses a N-terminal brain natriuretic peptide precursor detection kit and a detection method thereof; the kit includes: reagent one: phosphate buffer, preservative, Tween 20, polyethylene glycol 6000; reagent two: Phosphate buffer, disodium hydrogen phosphate, 2-5g / L sodium dihydrogen phosphate, sodium chloride, preservatives, sensitized latex particles of goat anti-human N-terminal-pre-B type natriuretic peptide antibody; calibrator: phosphoric acid Saline buffer solution, bovine serum albumin, sodium chloride, preservatives, N-terminal-pro-B-type natriuretic peptide antigen; method The latex immunoturbidimetric method was used to improve the sensitivity of the test, and to find a suitable detection method for the N-terminal pro-BNP Sensitized latex particles to improve detection sensitivity; through different automatic biochemical analyzers with different reagent-sample ratios, a large number of samples can be quantitatively detected at the same time; the kit contains calibrators to achieve the purpose of quantitative detection.

Description

technical field [0001] The invention relates to the field of in vitro diagnosis, in particular to an N-terminal brain natriuretic peptide precursor detection kit and a detection method thereof. Background technique [0002] In vitro diagnostic reagents refer to: they can be used alone or in combination with instruments, appliances, equipment or systems, and are used in the process of disease prevention, diagnosis, treatment monitoring, prognosis observation, health status evaluation and genetic disease prediction. Reagents, kits, calibrators (materials), quality control products (materials), etc. for in vitro detection of samples (various body fluids, cells, tissue samples, etc.). [0003] According to the level of product risk, in vitro diagnostic reagents are divided into the third category, the second category, and the first category of products. The third category of products: reagents related to the detection of pathogenic pathogen antigens, antibodies, and nucleic aci...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/82G01N33/68
CPCG01N21/82G01N33/6893G01N2021/825G01N2800/32
Inventor 黄争上吕伟军俞媛媛杨春超
Owner SHAOXING SHENG KANG BIOLOGICAL TECH
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