A kind of depacid cyclic ether compound and its preparation method and application

A technology of depsipepsyl acid cyclic ethers and compounds, which is applied in the field of depsipepsyl acid cyclic ethers and their preparation, and can solve serious problems such as loss of efficacy of antibiotics

Active Publication Date: 2021-04-02
GUANGDONG OCEAN UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, in clinical treatment, it is found that the drug resistance of pathogenic microorganisms is becoming stronger and stronger, especially methoxypenicillin-resistant Staphylococcus aureus (super drug-resistant bacteria), Pseudomonas aeruginosa (commonly known as Pseudomonas aeruginosa) and Candida albicans Infections caused by yeast (commonly known as Candida albicans) are becoming more and more serious, and many traditional antibiotics have basically lost their efficacy

Method used

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  • A kind of depacid cyclic ether compound and its preparation method and application
  • A kind of depacid cyclic ether compound and its preparation method and application
  • A kind of depacid cyclic ether compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Preparation of depsipphenolic acid cyclic ether compounds of the present invention:

[0062] Ⅰ. Fermentation

[0063] The marine fungus Aspergillus unguis 6-20-6 was inoculated in PSB culture based on static culture at 28°C for 20 days, adding appropriate amount of diatomaceous earth for filtration, and collecting mycelium and fermentation broth respectively.

[0064] Wherein, the fungal liquid culture medium consists of 500 mL of potato juice per liter, 500 mL of 20 g / L seawater prepared from natural coarse sea salt, 20 g of sucrose, and 5 g of peptone.

[0065] Wherein, the preparation method of the potato juice is as follows: peel the potatoes, wash them, add deionized water, heat to boil for 30 minutes, filter, boil 500mL of potato juice for every 200g of potatoes, and freeze them for preservation.

[0066] Ⅱ. Extraction

[0067] Add 300mL of NKA resin to every 500mL of the filtrate obtained in step I, shake well for 1 hour, and then transfer to the chromatography...

Embodiment 2

[0082] This example is an experiment on the activity of depsipphenolic acid cyclic ether compounds in inhibiting Gram-positive drug-resistant bacteria.

[0083] 1. Staphylococcus aureus is a very common bacteria, sometimes it will enter the human body and cause infection. The infection can range from mild sores and pimples on the skin to pneumonia or blood infection. Therefore, Staphylococcus aureus is an important target pathogenic microorganism for the development of new antibiotics.

[0084] 2. Experimental method:

[0085]The antimicrobial activity was initially screened using the international standard filter paper method, and the antimicrobial activity was measured by the diameter of the inhibition zone (Clinical and Laboratory Standards Institute.2012.Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard.Eleventh EditionM2-A11.); Sieve using a 96-well plate, adopt the international standard micro broth dilution method (National Committee...

Embodiment 3

[0090] This embodiment is an experiment on the activity of depsipphenolic acid cyclic ether compounds against Gram-negative bacteria.

[0091] 1. Pseudomonas aeruginosa is widely distributed in nature. This bacterium exists in all kinds of water, air, normal human skin, respiratory tract and intestinal tract. This bacterium often causes postoperative wound infection, and can also cause bedsores and abscesses , suppurative otitis media, etc.

[0092] Vibrio parahaemolyticus widely exists in the sea and in seafood, infection with this bacteria will cause acute onset, abdominal pain, vomiting, diarrhea and watery stool.

[0093] 2. Experimental method:

[0094] The antimicrobial activity was initially screened using the international standard filter paper method, and the antimicrobial activity was measured by the diameter of the inhibition zone (Clinical and Laboratory Standards Institute.2012.Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard.E...

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Abstract

The invention discloses a depsidone compound. A structural formula of the depsidone compound is shown in a formula I in the description. The depsidone compound is occasionally separated out when an inventor separates a fermenting product of aspergillus unguis 6-20-6. Proofed by experiment, the depsidone compound has the effect of inhibiting pseudomonas aeruginosa, methicillin-resistant staphylococcus aureus and candida albicans, and can be used for preparing anti-bacterial agents or anti-fungi agents.

Description

technical field [0001] The present invention relates to the field of biotechnology, more specifically, to a kind of depsipphenolic acid cyclic ether compound and its preparation method and application. Background technique [0002] At present, in clinical treatment, it is found that the drug resistance of pathogenic microorganisms is becoming stronger and stronger, especially methoxypenicillin-resistant Staphylococcus aureus (super drug-resistant bacteria), Pseudomonas aeruginosa (commonly known as Pseudomonas aeruginosa) and Candida albicans Infections caused by yeast (commonly known as Candida albicans) are becoming more and more serious, and many traditional antibiotics have basically lost their efficacy. [0003] Therefore, there is a need to search for novel antibacterial or antifungal agents. Contents of the invention [0004] In order to overcome the deficiencies of the existing antibacterial drugs, antifungal drugs and insecticides described in the above-mentioned...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/732C12P7/62A61P31/04A61P31/10C12R1/66
CPCA61P31/04A61P31/10C07C69/732C12P7/625
Inventor 张翼杨文聪鲍海燕刘亚月聂影影杨静明洪鹏志千忠吉宋采梁金月黎钊坪
Owner GUANGDONG OCEAN UNIVERSITY
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