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Preparation method of novel high-dispersity natamycin

A natamycin, high-dispersibility technology, applied in the field of preparation of new high-dispersion natamycin, can solve the problems of easy precipitation and uneven dispersion, increase of ingredients, low solubility, etc., to achieve maximum increase, Improves water solubility and the effect of using less

Inactive Publication Date: 2018-10-16
苏州汉德瑞生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ordinary natamycin has low solubility in liquid, easy to precipitate and unevenly dispersed, which greatly weakens its efficacy. Although the thickener can suspend it, if it is stored for too long, natamycin Can crystallize, adding unnecessary ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0021] The present invention will be specifically introduced below in conjunction with specific embodiments.

[0022] A preparation method for novel highly dispersible natamycin, comprising the following steps:

[0023] S1: Preparation of natamycin powder: Take a certain amount of dry mycelium and dissolve it in isopropanol, slowly add it dropwise, adjust the pH to 11-13, stir for 25-45min, filter the solution, and adjust the pH of the collected solution to 6-7, stirred for 2.5-3.5h, filtered, centrifuged, and dried in a spin flash dryer;

[0024] S2: Preparation of heat-saturated natamycin solution: Weigh a certain amount of natamycin powder and place it in a flask, slowly add pure water dropwise, continuously stir and heat during the dropwise addition, and the heating temperature is 85~95°C , until the mixed solution reaches a saturated state, stop adding pure water dropwise;

[0025] S3: Decolorization: Weigh a certain amount of activated carbon and place it in the prepar...

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PUM

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Abstract

The invention discloses a preparation method of novel high-dispersity natamycin. The preparation method comprises the following steps: preparing natamycin powder, preparing hot saturated natamycin solution, discoloring, filtering, suction filtering, and drying, thus obtaining high-dispersity natamycin crystals. According to the preparation method of the novel high-dispersity natamycin, by virtue of a re-crystallization technology, the water solubility of the natamycin can be improved, the maximization of active ingredients of the natamycin can be improved, the active ingredients can be uniformly distributed in water and suspended for a long time, and fewer precipitates are generated. In the food and beverage business, compared with the traditional natamycin, the use is more convenient, theconsumption can be reduced, and the efficacy and the cost performance are high.

Description

technical field [0001] The invention relates to a preparation method of natamycin, in particular to a preparation method of novel high-dispersion natamycin. Background technique [0002] Natamycin can not only widely and effectively inhibit the growth of various molds and yeasts, but also inhibit the production of mycotoxins, and can be widely used in food preservation and antifungal treatment. Natamycin has no inhibitory effect on bacteria, so it does not affect the natural ripening process of yogurt, cheese, raw ham, dry sausage. [0003] Ordinary natamycin has low solubility in liquid, easy to precipitate and unevenly dispersed, which greatly weakens its efficacy. Although the thickener can suspend it, if it is stored for too long, natamycin Will crystallize, adding unnecessary ingredients. Contents of the invention [0004] In order to solve the deficiencies in the prior art, the object of the present invention is to provide a preparation method of novel high-dispers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 杨保强
Owner 苏州汉德瑞生物工程有限公司