Parametric Design Method of Mosaic Structure Vascular Network in Skull Tissue Engineering

Abstract

The invention discloses a parametric design method for vascular nets with mosaic structures in skull tissue engineering. The method comprises the steps of: 1, extracting vascular features of a diploicvein: comparing the radius size of cavity structures through model preprocessing after reconstructing a skull model to distinguish porous structures from vein vascular structures and extracting the vascular features of the diploic vein, wherein the vascular features of the diploic vein comprise topological features and geometric features, the topological features reflect the distribution of bloodvessels in the space and the geometric features comprise vascular branch angles and vascular radii; and 2, designing a parametric model of a vascular structure: firstly, carrying out parametric design of a Mosaic structure, defining vascular pathways and finally generating a parametric vascular model with multi-level features. According to the method disclosed by the invention, through adjustingMosaic structure parameters, the density degree of the vascular nets can be adjusted and the vascular structure adjusting can be carried out for a certain area; and blood vessels can be uniformly andfully distributed in the set space; and therefore, the method is feasible in manufacturing a skull vascular stent.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and relates to a parametric design method for a mosaic structure (mosaic structure) vascular network of skull tissue engineering. Background technique [0002] The bioactive artificial bone substitute developed by bone tissue engineering technology can repair and reconstruct the damaged skull tissue, thereby maintaining or improving the function and structure of the skull, and has a good clinical application prospect. However, in the in vitro cell integration study of the skull porous scaffold, it was found that the survival rate of bone cells was low and the osteogenesis was slow, especially for large-area scaffolds, a large number of cells died in the center of the first week of implantation, the main reason The problem of vascularization is not considered in the scaffold. There is no vascular structure in the scaffold, and the blood supply and oxygen supply of the cells are limited,...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the lack of vascular structure of skull tissue engineering scaffolds limits the growth of cells and the formation of osteoblasts, a parametric design method of Mosaic structure vascular network based on the characteristics of veins and vessels of human skull plate barrier is proposed.

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