Application of miR-125b and chemotherapeutic agent in preparation of drug for treating thyroid cancer

1. The technology of mir-125b and thyroid cancer, which is applied in the field of biomedicine, can solve problems such as tumor occurrence, and achieve the effect of enhancing sensitivity and increasing autophagy
CN108721318AActive Publication Date: 2018-11-02GUANGDONG PHARMA UNIV +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG PHARMA UNIV
Publication Date
2018-11-02

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Abstract

The invention belongs to the field of biomedicines and relates to an application of miR-125b or a mimic or an accelerant thereof in preparation of a chemotherapeutic drug synergist. Studies find thatthe expression of Foxp3 is up-regulated when miR-125b is down-regulated in a thyroid cancer tissue sample. Besides, miR-125b can be combined with 3'UTR of miR-125b to directly act on Foxp3 and inhibitexpression of Foxp3, and therefore, the negative correlation between miR-125b and Foxp3 is disclosed. Overexpressed miR-125b remarkably increases the sensitivity of sensitized thyroid cancer cells totreatment with a chemotherapeutic agent through induction, and in-vitro and in-vivo autophagy is performed through an Atg7 way. In general, miR-125b negatively controls autophagy of an Foxp3 promotednew mechanism and enhances the curative efficacy of the chemotherapeutic agent for thyroid cancer, and it indicates that miR-125b has a remarkable treatment significance in chemotherapy of the thyroid cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to the application of miR-125b or a miR-125b promoter and a chemotherapeutic agent in the preparation of antitumor drugs. Background technique

[0002] Thyroid cancer accounts for 90% of endocrine malignancies and about 1% of all human malignancies. It is estimated that there were approximately 62,450 new cases of thyroid cancer in the United States in 2016. Although surgery has been the mainstay of treatment for thyroid cancer for decades, some patients still experience recurrence [1,2]. It is crucial to find potential markers and prognostic indicators for patients with thyroid cancer [3].

[0003] MicroRNA (miRNA) is an endogenous single-stranded non-coding RNA that plays an important role in various biological processes such as cells, including proliferation, adhesion and differentiation. It is estimated that more than one-third of human genes are targeted by miRNAs [4]. Increasing ev...

Claims

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