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A kind of preparation method and application of phbv/rosiglitazone slow-release film

A slow-release film and solution technology, applied in the field of medicine, can solve the problem of short drug action time and achieve the effect of less side effects

Inactive Publication Date: 2021-02-02
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although rosiglitazone formulated as eye drops with a concentration of 0.5% or subconjunctival injection has definite anti-scar effect and few side effects, the action time of the drug is short and repeated medication is required

Method used

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  • A kind of preparation method and application of phbv/rosiglitazone slow-release film
  • A kind of preparation method and application of phbv/rosiglitazone slow-release film
  • A kind of preparation method and application of phbv/rosiglitazone slow-release film

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Experimental program
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Embodiment Construction

[0030] The technical solutions of the present invention will be further described in detail below in conjunction with specific embodiments.

[0031] Rosiglitazone / PHBV release, degradation, in vivo experiments:

[0032] In the in vivo experiment, the rosiglitazone / PHBV membrane was placed on the surgical site, that is, under the conjunctiva, and its anti-scar effect was observed.

[0033] Such as figure 1 Rosiglitazone / PHBV membranes are shown. figure 2 It is the photomicrograph of rosiglitazone / PHBV film after electrospinning.

[0034] The present invention will be further described below in conjunction with specific analysis.

[0035] 1. Preparation of different concentrations of rosiglitazone / PHBV sustained-release films

[0036] Using the electrospinning method, adjust the spinning voltage, the advancing speed of the syringe pump, the distance between the syringe needle and the receiving plate, the ambient temperature, and the humidity to prepare rosiglitazone / PHBV sl...

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Abstract

The invention discloses a preparation method and application of a PHBV / rosiglitazone sustained-release film, which belongs to the technical field of medicine. After mixing PHBV powder, chloroform and dimethylformamide, it is configured into a PHBV with a mass-volume ratio of 5%. ‑TCM / DMF silk solution for use. Rosiglitazone was dissolved in dimethyl sulfoxide solution to prepare RSG / DMSO solutions with different concentration gradients. Add it into the spinning solution, configure the spinning solution with different final concentrations, transfer it into a glass syringe, and perform electrospinning to form a rosiglitazone / PHBV slow-release film, which is used in anti-glaucoma filtration surgery. It is safe and It has very important clinical significance to effectively and durably prevent scar formation after glaucoma surgery and improve the long-term success rate of glaucoma surgery.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method and application of a PHBV / rosiglitazone sustained-release film. Background technique [0002] Glaucoma is a neurodegenerative disease characterized by progressive vision loss and visual field defect. It is the leading cause of irreversible blindness worldwide and one of the preventable and controllable blinding eye diseases. The ultimate goal of glaucoma treatment is to control intraocular pressure and protect the optic nerve. The method of controlling intraocular pressure mainly contains medicine, laser, surgical treatment. Surgical treatment is glaucoma filtration surgery (GFS), which is also the main method for the treatment of glaucoma today. However, the excessive proliferation of Tenon's capsule fibroblasts (human tenon's fibroblasts, HTFs) after surgery leads to scarring of the filtration tract, making The 1-year failure rate after GFS is as high as 1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/34A61K31/4439A61P27/06A61P27/02
CPCA61K9/0048A61K9/7007A61K31/4439A61K47/34A61P27/02A61P27/06
Inventor 段宣初刘海蓉张凤黄宇婷刘可潘政
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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