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Small molecule compounds with immunomodulatory and antiviral effects

A compound and anti-virus technology, which can be used in anti-viral agents, organic active ingredients, and resistance to vector-borne diseases, etc. It can solve the problems of poor protein stability, obvious side effects, and high cost

Active Publication Date: 2021-03-23
杨威
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although different forms of interferon have been on the market as drugs for many years, as a protein drug, interferon often needs to be administered by injection, with obvious side effects, poor compliance, poor protein stability, harsh conditions in transportation and storage, and high costs. Improvements

Method used

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  • Small molecule compounds with immunomodulatory and antiviral effects
  • Small molecule compounds with immunomodulatory and antiviral effects
  • Small molecule compounds with immunomodulatory and antiviral effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1, the application of small molecular compound

[0070] The chemical structural formula of the small molecule compound that adopts below is as shown in following formula I:

[0071]

[0072] In formula I, R 0 for

[0073] in, R 1 At least one selected from F, Cl, Br and an alkoxy group with a total of 1-6 carbon atoms; R 1 The number of is one, two or three; R 1 The substituent position of is any substituent position on the phenyl group, such as at least one of para-position, ortho-position and meta-position.

[0074] in, R 2 is F, Cl or Br, R 2 The substituent position is any substituent position on the cyclopentyl group.

[0075] the above Among them, the above-mentioned alkoxy group whose total number of carbon atoms is 1-6 is -OCH 3 or -CH 2 OCH 3 .

[0076] The compound shown in the above formula I is the compound shown in formula I-1 or formula I-2;

[0077]

[0078] The compound shown in the above formula I-1 is Y-259, Y-911, ...

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PUM

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Abstract

The invention discloses small molecule compounds with immunomodulatory and antiviral effects. The invention provides application of the small molecule compounds with immunomodulatory and antiviral effects in any of antivirus or viral inhibition, activation of the innate immune pathway, preparation of antiviral or virus-inhibiting products, and preparation of products activating the innate immune pathway. Experiments show that the small molecule compounds represented by the general molecular formula, which are finally obtained through multiple rounds of high-throughput screening and structuraloptimization of a compound library and antiviral tests, have the activity of activating innate immunity and inhibiting various viral infections; the small molecule compounds or drugs have the effect of activating the innate immune pathway.

Description

technical field [0001] The invention belongs to the field of biomedicine, relates to the field of immune regulation and anti-infection, in particular to a small molecular compound with immune regulation and antiviral effects. Background technique [0002] Viral infection is a class of diseases that seriously threaten the health of humans and animals, and can be divided into acute infectious diseases and chronic (or latent) infectious diseases. In recent years, the number of new AIDS cases and deaths caused by human immunodeficiency virus type 1 (HIV-I) infection has shown a rapid upward trend. There are hundreds of millions of people chronically infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) worldwide, and the resulting liver cirrhosis and hepatocellular carcinoma are important lethal factors. Human herpesvirus (HHV) and papillomavirus (HPV) infections are closely related to the occurrence of malignant tumors such as nasopharyngeal carcinoma and cervical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/428A61P31/14A61P31/20A61P31/18A61P31/16A61P31/22
CPCA61K31/428A61P31/14A61P31/16A61P31/18A61P31/20A61P31/22Y02A50/30
Inventor 杨威
Owner 杨威