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Novel male contraception gel system

A male, gel technology, used in sexual diseases, fluid delivery, organic active ingredients, etc., can solve the problems of secondary injury to the body, difficult to popularize, etc., and achieve the effect of restoring the ability to ejaculate

Active Publication Date: 2018-11-16
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when it is necessary to restore fertility, it is necessary to inject sodium bicarbonate flushing hydrogel into the vas deferens through a second operation. The operation process will cause secondary damage to the body, so it is difficult to popularize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: a kind of novel male contraceptive gel system, its preparation method is:

[0035] Step 1: Synthesis of calcium alginate hydrogel: prepare a sodium alginate solution with a mass fraction of 2%, then take 4.9 g of sodium alginate solution, add 0.1 g of calcium carbonate, and stir evenly at room temperature. Then quickly add 0.2g of gluconolactone, stir and mix well for 30s.

[0036] Step 2: Prepare 0.1M EDTA solution.

[0037] The third step: configure the mixture of PEG and nano-gold, which is divided into two steps:

[0038] 1) Synthesis of gold nanoparticles

[0039] Using citric acid reduction method: take 3ml of 0.029M chloroauric acid solution in a three-necked flask, and heat at 160-170°C at 450rpm. After it boils, add 7ml of 1%wt trisodium citrate solution, continue to stir and heat for 15 minutes, then stop heating, continue to stir for 15 minutes, cool to room temperature, centrifuge twice at 11000rpm, remove the supernatant, Wash with deioniz...

Embodiment 2

[0043] Example 2: Simulating the vas deferens with transparent tubes of different diameters

[0044] Utilize commercially available hoses (1.5mm and 3mm) of disposable infusion sets, and PVC transparent hoses (6mm and 8mm) to simulate animal vas deferens of different diameters, and inject PEG / nano gold, EDTA, PEG sequentially into the hoses / Nano-gold, calcium alginate hydrogel four-segment drug, each segment reaches a height of 1cm, after infrared heating for 5 minutes, the time required for the detection system to completely degrade. The results are shown in the appendix of the manual figure 2 .

Embodiment 3

[0045] Example 3: Drug injection into rat vas deferens

[0046] 1) Prepare 10 healthy and fertile SD rats and anesthetize them with a small animal anesthesia machine at a dose of 0.3ml / 100g.

[0047] 2) After the rat was anesthetized, its limbs were fixed on the operating table with medical glue, and the abdomen was exposed.

[0048] 3) Shave the abdomen, wipe it with 75% alcohol, open the abdominal cavity about 3cm longitudinally, clamp the fat and gently pull out one testis to find the vas deferens.

[0049] 4) Fix a section of the vas deferens with two hemostatic clips, inject drugs in the middle, and inject 0.02ml of PEG / nano-gold, EDTA, PEG / nano-gold, and calcium alginate hydrogel sequentially from the direction of sperm outflow.

[0050] 5) Gently put the testis and vas deferens back into the abdominal cavity, and do the same for the vas deferens on the other side.

[0051] 6) Finally, the peritoneum and skin were sutured, and the rat was placed in a clean cage until i...

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Abstract

The invention provides a novel male contraception gel system. According to the novel male contraception gel system, calcium alginate hydrogel (SA), an EDTA (Ethylene Diamine Tetraacetic Acid) solutionand polyethylene glycol (PEG) / nano gold (AuNps) are combined for the first time and a contraception system can be noninvasively relieved at any time through infrared irradiation. The novel male contraception gel system is a simple, efficient and reversible male contraception method.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to the establishment of a novel male contraceptive gel system. Background technique [0002] With the development and progress of society and the change of people's ideas, the demand for contraception in modern society is also increasing. An estimated 85 million unintended pregnancies occur worldwide each year, half of which end in abortion and 13% end in unintended miscarriage. In developing countries, as of 2012, an estimated 222 million people had an unmet need for contraception. For decades, women have shouldered the burden of contraception, but long-term use of contraceptive pills can cause physical damage. And in the world of male contraception -- there are few alternatives to condoms and vasectomy. Although condoms protect against STDs, condoms impair sexual quality and have a high failure rate (~19%); vasectomy, while highly effective (99%), is poorly reversible (<5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/734A61K31/77A61K31/198A61K9/06A61P15/16
CPCA61K9/0019A61K9/0034A61K9/06A61K31/198A61K31/734A61K31/77A61K33/24A61P15/16A61K2300/00
Inventor 王小磊辛洪波鲍伟伟谢琳
Owner NANCHANG UNIV
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