Effect of ws6 on actin formation in trabecular meshwork cells

A technology of actin and trabecular meshwork, applied in the medical field, can solve problems such as high intraocular pressure and achieve the effect of reducing intraocular pressure
CN108836971BActive Publication Date: 2020-10-30QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QINGDAO UNIV
Publication Date
2020-10-30

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Abstract

The invention discloses influence of WS6 on actin formation of trabecular meshwork cells. WS6 refers to anti-diabetic medicine glibenclamide, sodium orthovanadate and an active compound capable of promoting pancreatic beta cell proliferation. WS6 has cytotoxicity on the trabecular meshwork cells and inhibits actin formation of the trabecular meshwork cells. The influence of WS6 has the beneficialeffect that the fact that WS6 can remarkably inhibit actin formation, caused by TRPV4 agonist GSK101, of the trabecular meshwork cells is revealed. Intraocular pressure can be reduced, and the influence of WS6 has potential treatment significance in glaucoma caused by increase of intraocular pressure.
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Description

Technical field

[0001] The invention belongs to the field of medical technology, and relates to the effect of WS6 (a drug for promoting islet cell proliferation) on the formation of actin in trabecular meshwork cells. Background technique

[0002] Glaucoma (Glaucomas) is a kind of optic nerve disease caused by degeneration of retinal ganglion cells, which can cause optic disc depression, visual field defect, and eventually blindness.

[0003] Studies have shown that high intraocular pressure is an important treatment factor for glaucoma. Every 1mm Hg reduction in intraocular pressure can reduce the progress of glaucoma by approximately 10%. The high intraocular pressure is mainly caused by the imbalance of the aqueous circulation in the anterior segment. Aqueous humor is produced in the ciliary body, enters the aqueous circulation of the anterior segment of the eye through the narrow gap between the iris and the lens, and then is discharged from the eye through the drainage of aq...

Claims

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