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Fermented formula with non-digestible oligosaccharides

A technology for digesting oligosaccharides and oligosaccharides, which is applied in the field of infant nutrition and can solve the problems of undisclosed fermentation ingredients and lactic acid

Pending Publication Date: 2018-11-23
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this document does not disclose fermented ingredients and lactic acid

Method used

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  • Fermented formula with non-digestible oligosaccharides
  • Fermented formula with non-digestible oligosaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Synergistic effect of fermented infant formula and indigestible oligosaccharides on infant secretory IgA levels

[0076] In a randomized, double-blind, controlled, parallel group, prospective, multi-center, multi-country, intervention study, the subjects were equally randomized into four treatment groups. In addition, infants who have been exclusively breastfed since birth (never received any infant formula) and whose mother intends to continue exclusive breastfeeding until the baby is at least 4 months old are included in the breastfeeding reference group. A total of 350 subjects were enrolled in the group, of which 280 subjects were randomly given any of the four test products, and 70 subjects were included in the breastfeeding reference group.

[0077] Test group 1: Infant formula 1 is a modified milk-based infant formula (Nutrilon 1, sold by Nutricia, the Netherlands) for bottle-fed infants aged 0-6 months. The formula contains non-digestible oligosaccharides...

Embodiment 2

[0093] Example 2: Consumption of fermented infant formula containing indigestible oligosaccharides increases intestinal sIgA levels

[0094] In a randomized, multicenter, double-blind, prospective clinical trial, infants were enrolled before 28 days of age and were designated to receive one of three formulas until 17 weeks of age:

[0095] Test group 1: Infant formula 1 contains 66kcal per 100ml, 1.35g protein (bovine whey protein / casein, weight ratio 1 / 1), 8.2g digestible carbohydrates (including 5.6g lactose and 2.1g maltodextrin) , 3.0g fat (mainly vegetable fat), 0.8g contains scGOS with a weight ratio of 9:1 (source GOS) and lcFOS (source ) Of indigestible oligosaccharides. Based on dry weight, about 50% of the infant formula is derived from Lactofidus TM , A commercially available infant formula sold under the trade name Gallia. Lactofidus TM It is a fermented milk derived composition prepared by fermentation with Streptococcus thermophilus and contains Bifidobacterium...

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Abstract

A fermented formula comprising non digestible oligosaccharides synergistically stimulates secretory IgA in infants.

Description

Technical field [0001] The invention relates to the field of infant nutrition for improving the immune system. Background technique [0002] It is generally believed that the best nutrition for newborn babies is human milk. When mothers are unable to breastfeed their babies or choose not to breastfeed, infant formula (IF) based on mature human milk is considered the best alternative. Research to improve the quality of infant formula is not necessarily to simulate the precise composition of human milk, but to achieve functional effects beyond the nutritional aspects observed in breastfed infants. [0003] Human milk is rich in secretory IgA (sIgA), which serves as the first line of defense to protect the baby's intestinal barrier from intestinal toxins and pathogenic microorganisms. sIgA is resistant to digestive enzymes, and promotes their removal from the intestine by blocking antigens and pathogenic microorganisms from entering epithelial cell receptors, trapping them in mucus,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L33/135A23L33/21A61K31/702A61K35/744A61K35/745A61P37/04
CPCA61K31/702A61K35/745A23L33/40A23L33/135A23L33/21A61P37/04A23L33/00
Inventor J·科诺尔H·鲍里迪尤斯A·R·奥泽尔A·J·纳奥塔
Owner NV NUTRICIA
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