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Method for evaluating skin health

An evaluation method and skin technology, applied in health index calculation, instrument, chemical information database system, etc., can solve the problems of skin health impact and inability to evaluate skin health

Active Publication Date: 2018-11-23
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is clear that the health of the skin cannot be evaluated scientifically at the molecular level if it is judged by the appearance of the skin
[0003] In addition, it is known that lipids in the stratum corneum of the skin are components that participate in the barrier function or water retention function of the skin at the molecular level and have a large impact on the health of the skin.

Method used

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  • Method for evaluating skin health
  • Method for evaluating skin health
  • Method for evaluating skin health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0264] Example 1 Correlation between atopic dermatitis and ceramide components

[0265] (1) Subjects

[0266] Eight atopic dermatitis patients (16-36 years old) who often went to dermatology hospitals and 7 healthy normal volunteers (25-37 years old) corresponding to the above ages

[0267] (2) Determination of stratum corneum function

[0268] For patients with atopic dermatitis, it is applied to the rash area of ​​the arm and the adjacent non-eruption area. For healthy people, it is applied to the same area of ​​the arm as the patient. After washing the target area with detergent, Acclimate for 5 minutes. Then, the measurement of the stratum corneum moisture content (Capacitance (AU)) using a skin moisture meter (Corneometer CM825, manufactured by Courage+Khazaka Company) and the measurement of the moisture content using a skin moisture loss tester (Tewameter TM300, manufactured by Courage+Khazaka Company) were carried out. Transepidermal water evapotranspiration (TEWL (g...

Embodiment 2

[0314] Example 2 Correlation between psoriasis and ceramide components

[0315] (1) Subjects

[0316] Ten psoriasis patients (36-74 years old) who often went to dermatology hospitals and 9 healthy normal volunteers (39-76 years old) corresponding to the above ages.

[0317] (2) Determination of stratum corneum function

[0318] For psoriasis patients, it is for the erythra portion of the arm and the adjoining non-rash portion. For healthy people, it is for the same position of the patient on the arm. skin moisture evapotranspiration.

[0319] (3) Collection of skin stratum corneum

[0320] For psoriasis patients, tape (PPS tape, manufactured by Nichiban Co., Ltd.) was pressed on the rash and the adjacent non-rash portion of the arm where the stratum corneum function had been measured. Adhesive tape, manufactured by Nichiban Co., Ltd.) was pressed on the same part of the arm as that of the patient, and the stratum corneum of the skin (2.5 cm x 4 cm x 10 pieces) was peeled o...

Embodiment 3

[0331] Embodiment 3 Correlation between skin quality and ceramide components

[0332] (1) Subjects

[0333] 210 healthy women aged 20-25 to 70-75 living in the suburbs of Tokyo (average age 45.9 years)

[0334] (2) Collection of stratum corneum

[0335] The stratum corneum (2.5 cm x 4 cm x 4 pieces) was continuously collected four times from the same site of the cheek of each test subject by the tape peeling method. An acrylic adhesive tape (manufactured by Teraoka Seisakusho) was used as the adhesive tape. Each tape was cut in half, and one half was used for the analysis of the ceramide component, and the other half was used for the quantification of the protein. Protein quantification was performed by adding 0.1N NaOH and 1% SDS aqueous solution to the half-cut tape, heating at 60°C for 2 hours to dissolve the protein, cooling to room temperature, adding 2N HCl for neutralization, and using BCA protein quantitative analysis reagent (BCA Protein Assay), quantitative value...

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Abstract

Provided is a method for evaluating skin health, which method comprises: preparing a lipid sample from collected stratum corneum of skin of a subject; determining the quantities of a ceramide component A and a ceramide component B contained in the prepared lipid sample of the subject, the ceramide component A being selected from the group consisting of a non-hydroxyacyl-phytosphingosine ceramide component, a non-hydroxyacyl-6-hydroxysphingosine ceramide component, an ester-omega-hydroxyacyl-6-hydroxysphingosine ceramide component, and an ester-omega-hydroxyacyl-phytosphingosine ceramide component, and the ceramide component B being selected from the group consisting of a non-hydroxyacyl-sphingosine ceramide component and an alpha-hydroxyacyl-sphingosine ceramide component; calculating theratio of the determined quantity of the ceramide component A to the determined quantity of the ceramide component B; and evaluating skin health of the subject from the calculated ratio.

Description

technical field [0001] The present invention relates to a skin health evaluation method and a skin health evaluation device. Background technique [0002] Presence or absence of atopic dermatitis or psoriasis; age-related changes in skin such as wrinkles and sagging; skin color or luster; blood flow in the skin; moisture, dryness, or oiliness The state of health can be evaluated to some extent by visually judging the skin. However, it is clear that the health of the skin cannot be evaluated scientifically at the molecular level if it is judged by the appearance of the skin. [0003] In addition, it is known that lipids in the stratum corneum of the skin participate in the barrier function and water retention function of the skin at the molecular level, and are known to have a large impact on the health of the skin. Here, the term "lipid" refers to a bioderived molecule having a long-chain fatty acid or hydrocarbon chain, and includes fatty acid, glyceride, wax ester, sphin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N30/72G01N30/88G01N33/92
CPCG01N33/92G16H50/20G16H50/30G01N33/5082H01J49/26G16C20/90G01N30/7233G01N2405/08G01N2800/202G01N2800/205G01N2800/207G01N33/50G01N30/72G01N30/88
Inventor 石川准子横瀬丽志摩恭子诸隈由树
Owner KAO CORP