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Controllable degradable biohydraulic membrane and its production method and application

A production method and technology of hydrogel film, applied in medical science, prosthesis, etc., can solve the problems of inconvenient transportation and use, damage to tissues and organs in the body, inaccurate analysis and research, etc., and achieve accurate and accurate pathological research and therapy research. Conducive to the effect of controllable self-organization molding

Active Publication Date: 2021-02-09
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, when constructing complex layered tissues, it is difficult to form a good and long-term stable layered structure without the use of biofilms, and it is difficult to remove them after tissue formation when biofilms are used. Therefore, there are inaccurate problems in analysis and research. There is a risk of damaging tissues and organs in the body during tissue repair
In addition, the current biomembranes still have the problems of single fine structure and inconvenient storage, transportation and use of ultra-thin biofilms.

Method used

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  • Controllable degradable biohydraulic membrane and its production method and application
  • Controllable degradable biohydraulic membrane and its production method and application
  • Controllable degradable biohydraulic membrane and its production method and application

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Embodiment Construction

[0033]The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary, and is not intended to limit the scope of the present invention and its application.

[0034]Refer tofigure 1 withFigure 2c In one embodiment, a controllable degradable biological hydrogel film includes: at least one layer of hydrogel film 2 between two layers of dielectric film 1, a layer of dielectric film 1 and a layer of hydrogel The membrane 2 constitutes a unit structure 3; at least two layers of dielectric membrane 1 that can be detached from the hydrogel membrane 2 are used to encapsulate and protect the hydrogel membrane 2; wherein the hydrogel membrane 2 is a variety of Biocompatibility and biodegradability of medical hydrogel materials are formed by layering and / or cross-arrangement and / or uniform mixing, so as to achieve the gradual degradation of different materials and produce different microstructures to induce tissue...

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Abstract

A controllable degradation biohydration film and its production method and application, the controllable degradation biohydration film comprises: at least one layer of hydrogel film between two layers of medium film; At least two layers of dielectric film peeled off from the film are used to encapsulate and protect the hydrogel film; wherein the hydrogel film is a variety of biocompatible and biodegradable medical hydrogel materials for lamination and / or cross-arranged and / or uniformly mixed to achieve the gradual degradation of different materials and produce different microstructures to induce the directional arrangement and characterization of cells in the tissue engineering process. The layered tissue constructed using the controllable degradable hydrogel film has a more bionic structure and physiological environment, which is more accurate when applied to drug screening, pathology research and therapy research, and safer when applied to tissue transplantation.

Description

Technical field[0001]The present invention relates to the field of tissue engineering, in particular to a controllable degradable biological hydrogel and its manufacturing method and application.Background technique[0002]At present, in the process of drug screening, pathological research, therapy research, and organ repair and replacement, it is necessary to use tissue engineering methods to restore the complex tissues of large organs in vitro, and complex tissues contain complex layered structures. In the process of constructing these complex layered structures, diaphragms with good mechanical properties are required to ensure the long-term stable maintenance of the layered structure; and after the complex tissues are formed by biological self-organization, in order to avoid the adverse effects of foreign bodies, these diaphragms need to be Remove without damaging the structure.[0003]At present, when constructing complex layered tissues, it is difficult to form a good and long-term...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/22A61L27/50A61L27/58
CPCA61L27/222A61L27/50A61L27/58
Inventor 弥胜利王杰琼易晓满
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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