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Application of human urinary kallikrein in preparation of medicine for treating thromboangiitis obliterans

A technique for urokininogenase and thrombus occlusion, applied in the field of medicine, can solve problems such as poor clinical effect, achieve significant therapeutic effect, improve blood rheology, and reduce blood rheological value.

Active Publication Date: 2020-03-24
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the treatment of thromboangiitis obliterans is mainly based on anti-platelet aggregation, improving microcirculation and vasodilator drugs, but a large number of medical studies have confirmed that the clinical effect is not good

Method used

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  • Application of human urinary kallikrein in preparation of medicine for treating thromboangiitis obliterans
  • Application of human urinary kallikrein in preparation of medicine for treating thromboangiitis obliterans
  • Application of human urinary kallikrein in preparation of medicine for treating thromboangiitis obliterans

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, preparation human urinary kininogenase injection

[0018] Take 3 mg of human urinary kininogenase that was sterilized by filtration, add 6 g of dextran and 1 g of sodium citrate, add water for injection to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, and make sterile Filter, pack in 1000 ampoules, and get ready.

Embodiment 2

[0019] Embodiment 2, preparation human urinary kallikrein injection

[0020] Take 3 mg of human urinary kininogenase that was sterilized by filtration, add 5 g of dextran and 2 g of sodium citrate, add water for injection to dissolve, adjust the pH to neutral, add water for injection to 500 ml, add sodium chloride to adjust isotonicity, and make sterile Filter, pack in 1000 ampoules, and get ready.

Embodiment 3

[0021] Embodiment 3, preparation human urinary kininogenase lyophilized powder

[0022] Take 2 mg of human urinary kininogenase that was sterilized by filtration, add 8 g of hydrolyzed gelatin, 5 g of dextran, 3 g of sodium citrate and 1 g of lactose, add water for injection to dissolve, adjust the pH to neutral, add water for injection to 500 ml, and filter aseptically , packed into 1000 ampoules, and freeze-dried under sterile conditions, that is.

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PUM

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Abstract

The invention belongs to the technical field of medicines and particularly relates to a use of human urinary kalliainogenase in preparing a drug for treating thromboangiitis obliterans. Proved by tests, the human urinary kalliainogenase can reduce the amount of thrombi formed in blood vessels, improves hemorheology and has the therapeutical effect to the thromboangiitis obliterans. The invention provides new application of the human urinary kalliainogenase in the field of the medicines, namely the human urinary kalliainogenase can be used as the drug for treating the thromboangiitis obliterans, expands an application range of the human urinary kalliainogenase and provides a new selection to general patients with the thromboangiitis obliterans.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the use of human urinary kininogenase in the preparation of medicines for treating thromboangiitis obliterans. Background technique [0002] Human Urinary Kallidinogenase (Human Urinary Kallidinogenase) is a refined glycoprotein extracted from the urine of healthy men, with a molecular weight of about 54,000 Daltons. It can activate the conversion of human plasma kininogen into kinin, dilate blood vessels and increase blood flow. Improve blood circulation, and also increase the deformability of red blood cells and inhibit platelet aggregation, prolong recalcification time and improve blood viscosity. In recent years, with the in-depth research on human urokininogenase, more and more new uses of human urokininogenase have been found. For example, Chinese patent CN101879308B discloses the application of human urinary kininogenase in the preparation of drugs for treatin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/48A61P9/14
CPCA61K9/0019A61K38/4853A61P9/14C12Y304/21008
Inventor 杨磊宋健东张志军严铭娟徐虹
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD