Unlock instant, AI-driven research and patent intelligence for your innovation.

Label-free biosensor based on optical fiber polarization modulation and its realization method

A biosensor and polarization modulation technology, applied in the direction of polarization influence characteristics, can solve the problems of difficult research, small size, high system cost, etc., and achieve the effect of simple operation and low cost

Active Publication Date: 2021-04-06
中物慧芯信息科技(苏州)有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the extremely small size of the above-mentioned optical fiber devices, very careful operations are required to complete, making research extremely difficult
In addition, the vast majority of label-free fiber optic biosensors carry out biological monitoring based on the wavelength shift of the sensor spectrum, expensive spectral analysis equipment is essential, and the system cost is extremely high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Label-free biosensor based on optical fiber polarization modulation and its realization method
  • Label-free biosensor based on optical fiber polarization modulation and its realization method
  • Label-free biosensor based on optical fiber polarization modulation and its realization method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Such as figure 1 As shown, the label-free biosensor based on optical fiber polarization modulation of the present invention includes:

[0041] A spontaneous emission light source 7, used to generate non-polarized light;

[0042] Pipeline 3, the interior of the pipeline 3 is provided with a functionalized magnetic nanoparticle suspension 2;

[0043] The target biomolecule 4 is added to pipeline 3 for monitoring;

[0044] A light polarization modulation device 5, used for polarization modulation of light by using functionalized magnetic nanoparticles;

[0045] A polarization detection system 8, configured to detect the modulation of the polarization state of light in the optical polarization device 5;

[0046] an electromagnet for generating a magnetic field;

[0047] Wherein, the spontaneous radiation light source 7 is located on one side of the pipeline 3 , the light polarization modulation device 5 is located in the center of the pipeline 3 , and the light polariza...

Embodiment 2

[0055] The implementation method of the label-free biosensor based on optical fiber polarization modulation of the present invention comprises the following steps:

[0056] S1: the spontaneous emission light source 7 emits unpolarized light, and the unpolarized light is coupled into the light polarization modulation device 5;

[0057] S2: The light polarization modulation device 5 is placed in the pipeline 3, and the light polarization modulation device 5 passes through the pipeline 3;

[0058] S3: distributing and setting the functionalized magnetic nanoparticle suspension 2 in the pipeline 3;

[0059] S4: adding target biomolecules 4 into the pipeline 3, the target biomolecules 4 are coupled with the bioprobe molecules on the surface of the functional magnetic nanoparticles, and induce self-assembly of the functional magnetic nanoparticles to form magnetic nanoparticle clusters;

[0060] S5: Using an electromagnet to apply a constant magnetic field;

[0061] S6: Remove the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a label-free biosensor based on optical fiber polarization modulation and its realization method, belonging to the technical field of label-free optical fiber biosensors, comprising: a spontaneous radiation light source for generating non-polarized light; Magnetic nanoparticle suspension; target biomolecules, which are added to the pipeline for monitoring; light polarization modulating devices, used for polarization modulation of light using functionalized magnetic nanoparticles; polarization detection systems, used for polarizing light in the light polarizing device The modulation of the polarization state is detected; the electromagnet is used to generate a magnetic field; the invention induces the polarization modulation of the optical fiber by the self-assembly of magnetic nanoparticles, and performs biosensing through the polarization detection of the optical fiber, without functionalization on the surface of the optical fiber device, and without expensive The spectral analysis equipment is simple in operation and low in cost, and solves the problems in the prior art.

Description

technical field [0001] The invention relates to a biosensor, in particular to a label-free biosensor based on optical fiber polarization modulation and a realization method thereof, belonging to the field of label-free optical fiber biosensors. Background technique [0002] Compared with electrochemical biosensors or free-space optical biosensors, optical fiber biosensors have the advantages of flexible structure, compact structure, and remote monitoring. In the past few years, many kinds of label-free fiber optic biosensors have been developed based on optical ring resonators, fiber interferometers, fiber gratings, fiber couplers, etc. [0003] However, the current label-free biosensors need to functionalize the surface of the optical device before biosensing, so as to achieve the purpose of specific adsorption. However, due to the extremely small size of the above-mentioned optical fiber devices, very careful operations are required to complete, making research extremely ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/21
CPCG01N21/21
Inventor 马任德夏云杰李晓平
Owner 中物慧芯信息科技(苏州)有限公司