Preparation method and application of camellia flower extracting solution

A camellia and extract technology, which is applied to skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of low column chromatography separation effect, low TLC separation volume, and uneconomical extraction time. and other problems, to achieve the effect of green extraction process, high efficiency and excellent antioxidant effect.

Active Publication Date: 2018-12-21
SHANGHAI FOREST CABIN BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As far as the current general separation and preparation methods are concerned, they mainly rely on traditional thin-layer chromatography and column chromatography to separate and prepare, but the separation capacity of thin-layer chromatography is very low, and the separation effect of column chromatography is not high, especially in the separation process. Using a large amount of organic solvents pollutes the environment and wastes costs, and the extraction time is not economical

Method used

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  • Preparation method and application of camellia flower extracting solution
  • Preparation method and application of camellia flower extracting solution
  • Preparation method and application of camellia flower extracting solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Select 100g of fresh, non-damaging and disease-free camellias, and use the refraction window drying technology to dry them to obtain dried camellia products; the conditions for refraction window drying are: circulating hot water with a water temperature of 90°C is used as a heating source, and the thickness of the camellias is 10mm. The cooling temperature is 10°C, the drying time is 30 minutes, and the relative humidity of the air in the drying chamber is 35%.

[0034] (2) Superfine pulverization through nitrogen protection airflow, the conditions are: air pressure 1.0MPa, system air volume 3.5m 3 / min, classifier speed 3000r / min, feeding speed 7.5kg / h; after crushing, pass through 400 mesh sieve;

[0035] (3) Put 1,3-butanediol / pentanediol / alanine / sorbitol into the quaternary system deep eutectic solvent (the molar ratio is 2:10:5:2, heat at 90°C Melt, the transparent liquid formed after cooling) 1000g, mix evenly, put into the ultrasonic container, the temperatu...

Embodiment 2

[0040] (1) Select 100g of fresh, non-damaging and disease-free camellias, and dry them using the refraction window drying technology to obtain dried camellia products; the conditions for refraction window drying are: circulating hot water with a water temperature of 87°C as the heating source, and the thickness of the camellias as 7mm, The cooling temperature is 12°C, the drying time is 24 minutes, and the relative humidity of the air in the drying chamber is 35%.

[0041] (2) Superfine grinding through nitrogen protection air flow, the conditions are: air pressure 0.8MPa, system air volume 4.0m 3 / min, classifier speed 2800r / min, feeding speed 7.0kg / h; after crushing, pass through 400 mesh sieve;

[0042] (3) Put 1,3-butanediol / pentanediol / alanine / sorbitol into the quaternary system deep eutectic solvent (the molar ratio is 2:8:6:1, heat at 90°C Melt, 800g of transparent liquid formed after cooling, mix evenly, and put it into an ultrasonic container, the temperature of the ...

Embodiment 3

[0047] (1) Select 100g of fresh, non-damaged and disease-free camellias, and dry them with the refraction window drying technology to obtain dried camellia products; the conditions for refraction window drying are: circulating hot water with a water temperature of 85°C is used as a heating source, and the thickness of the camellias is 3.0mm , the cooling temperature is 10°C, the drying time is 23 minutes, and the relative humidity of the air in the drying chamber is 38%.

[0048] (2) Superfine grinding through nitrogen protection air flow, the conditions are: air pressure 0.85MPa, system air volume 3.5m 3 / min, classifier speed 2850r / min, feeding speed 5.5kg / h; after crushing, pass through 400 mesh sieve;

[0049] (3) Put 1,3-butanediol / pentanediol / alanine / sorbitol into the quaternary system deep eutectic solvent (the molar ratio is 3:10:3:3.5, heat at 90°C Melt, 1200g of transparent liquid formed after cooling, mix evenly, put into the ultrasonic container, the material liqu...

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Abstract

The invention provides a preparation method and an application of a camellia flower extracting solution. The method comprises steps as follows: A, selecting fresh camellia flowers without damage and diseases, and drying the camellia flowers with a refraction window drying technology to obtain a dried camellia flower product; B, performing airflow superfine crushing and sieving on the dried camellia flower product, and adding a quaternary system deep-eutectic solvent for ultrasonic extraction to obtain an extracted mixture; C, mixing the extracted mixture and deionized water, regulating pH, andadding enzyme for enzymolysis; D, leaving a product to stand for a certain time after enzymolysis, and filtering the product to obtain the camellia flower extracting solution. According to the method, drying is performed with the refraction window drying technology, superfine crushing is performed, the non-toxic deep-eutectic solvent is taken as an extracting agent, and the production process issimple, efficient, safe and green; the defects that a large quantity of toxic organic solvents and complicated column separation processes are required for production of conventional epicatechin are overcome. The obtained extracting solution has the skin repairing efficacy, the bacteriostasis function and high antioxidation capability and is safe and non-irritant.

Description

technical field [0001] The invention belongs to the technical field of natural product extraction, and relates to a preparation method and application of a camellia extract. The obtained extract has skin repairing and antibacterial effects. Background technique [0002] Epicatechin belongs to catechins, and catechins are important phenolic substances. In addition to tocopherol, ascorbic acid, carotenoids, and alkaloids among the natural antioxidant components in plants, phenolic substances are the most widely distributed, most diverse and most abundant components. Studies have shown that epicatechin has a variety of biological activities such as scavenging free radicals, inhibiting tumors, anti-mutagenesis, anti-virus, inhibiting microorganisms, reducing fat and helping digestion, skin care and beauty. [0003] Epicatechin is insoluble in water, and traditional extraction methods often use organic solvents (such as methanol, ethanol, ethyl acetate, chloroform, n-butanol, et...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00
CPCA61K2800/10A61K2800/805A61K2800/82A61Q19/00A61K8/9789
Inventor 赵鑫黄静桑建梅高宏旗
Owner SHANGHAI FOREST CABIN BIOLOGICAL TECH
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