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Improved silk fibroin glycerol membranes

A technology of silk fibroin and silk protein, which is applied in medical science, ear implants, prostheses, etc., to achieve the effect of enhanced biocompatibility and enhanced solubility

Active Publication Date: 2018-12-21
EAR SCI INST AUSTRALIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, improving composite blends to enhance the mechanical and vibroacoustic properties of membranes used to repair the middle ear, including tympanic membrane perforations and injuries, remains a significant challenge in many cases

Method used

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  • Improved silk fibroin glycerol membranes
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  • Improved silk fibroin glycerol membranes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0063] The silk fibroin glycerol film matrix prepared according to the present invention is biodegradable, biocompatible, and compared with most other natural and synthetic biomaterials, such as collagen and polylactic acid (PLA), in its mechanical strength One or more of , elongation and stiffness are improved.

[0064] a. Silk Fibroin Glycerin Membrane Matrix

[0065] The invention provides a silk fibroin glycerin film matrix prepared in the presence of formic acid, wherein the film:

[0066] (a) comprising silk fibroin in an amount ranging from about 0.1% to about 20% (wt %) of the total wet weight of the film,

[0067] (b) comprising about 5% (w / w) to 60% (w / w) glycerol, and

[0068] Wherein the complex solution of glycerol and silk protein is dissolved in the presence of formic acid, and then dried to prepare the membrane matrix.

[0069] Silk fibroin is present in the film in an amount ranging from about 0.1% to about 10% (wt %) of the total wet weight of the film. ...

Embodiment

[0244] Materials and methods

[0245] Preparation of silk glycerin film

[0246] Undegummed fibers from the polymorphic silkworm (Bombyx mori) on reels were purchased from a production center in northeastern India. Fibers were degummed using 2 g / L sodium carbonate (Sigma-Aldrich, St. Louis, MO, USA) and 1 g / L odorless castile soap (Vasse Virgin, Wilyabrup, Western Australia, Australia) at 98°C for 30 min. Degumming was performed using a rotary staining machine (Ahiba IR Pro, Datacolor, Lawrenceville, USA). The degummed fibers were dried overnight at 40 °C and then dissolved with 9.3 M LiBr at 60 °C for 5 h. with dH 2 O The dissolved silk solution was dialyzed at 4°C for 3 days to obtain an aqueous silk solution with a concentration between 4 and 5% w / v as calculated by gravimetric analysis. Each batch of silk solution was diluted to 4%.

[0247] To prepare an aqueous film, weigh the required amount of glycerol into an empty tube. The required volume of 4% silk solution w...

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Abstract

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. The invention also provides for compositions and methods for preparing composite silk fibroin and glycerol membranes using formic acid, where the membranes have improved mechanical and vibroacoustic properties.

Description

technical field [0001] The present invention relates to the preparation of membranes for repairing the middle ear, including tympanic membrane perforations and injuries. The present invention also provides compositions and methods for preparing composite silk fibroin and glycerol films using formic acid, wherein the films have improved mechanical and vibroacoustic properties. Background technique [0002] The following discussion is intended only to facilitate an understanding of the present invention. The discussion is not an acknowledgment or admission that any of the material referred to is or was part of the common general knowledge as of the priority date of this application. [0003] Chronic perforation of the eardrum or tympanic membrane is relatively common and requires surgical intervention with graft material to cover the perforation, a technique known as type 1 myringoplasty or tympanoplasty. [0004] Autografts such as muscle fascia, fat, perichondrium, and car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/36A61L27/22A61L27/50C08J3/18C08J5/18C08K5/053
CPCC08J5/18A61L27/3604A61L27/3804A61L2430/14C08J2389/00C08J3/05C08K5/053A61L27/54A61F2/18A61L27/227A61F2002/183C08L89/00C08L2203/02
Inventor M·阿特拉斯R·迪莉B·阿勒代斯R·拉杰霍瓦
Owner EAR SCI INST AUSTRALIA
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