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Gel tissue plugging material and preparation method thereof, and plugging product

A technology for plugging materials and tissues, applied in application, medical science, surgery, etc., can solve the problems of poor adhesion, difficult to heal, low bursting strength, etc., and achieve excellent adhesion performance and bursting strength, easy molding, High security effect

Active Publication Date: 2019-01-01
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the adhesion is poor, and it is easy to fall off from the wound; the temperature around the wound is raised to cause a burn wound, which is difficult to heal; the speed of hemostasis and the amount of hemostasis are still not enough for a large number of rapid bleeding Emergency treatment requirements; liquid leakage cannot be stopped quickly; bursting strength is low, etc.

Method used

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  • Gel tissue plugging material and preparation method thereof, and plugging product

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no. 1 approach

[0046] like figure 1 As shown, in the first embodiment of the present invention, a gel tissue plugging material is provided, including: a base body 1, the base body 1 includes a gel layer; Layer 2, the wet adhesive layer 2 is obtained by contacting at least one surface of the substrate 1 with an adhesive solution, the adhesive solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer in the liquid.

[0047]The bursting strength of the gel tissue plugging material of the present invention is between 0.1Kpa-100Kpa, for example: it can be 1Kpa-100Kpa, it can also be 10Kpa-80Kpa, it can also be 20Kpa-60Kpa, it can also be 30Kpa-40Kpa; The elongation at break of the gel tissue plugging material of the present invention is between 1%-1500%, may be 10%-1200%, may also be 100%-1000%, may also be 200%-800%, or It can be 400%-600%.

[0048] The gel tissue plugging material of the present invention has excellent tissue adhesion performance, e...

no. 2 approach

[0074] In the second embodiment of the present invention, a method for preparing a gel tissue plugging material is provided, including the step of composite molding the matrix and the wet adhesive layer, wherein,

[0075] The matrix includes a gel layer;

[0076] The wet adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution;

[0077] The adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer.

[0078] In the present invention, the substrate may be ready-made, or the pre-prepared finished substrate may be directly compounded with the wet adhesive layer.

[0079] In the present invention, the preparation method of the matrix includes: performing cross-linking treatment on the matrix solution. The solute of the matrix solution contains one or a combination of two or more polymers or their derivatives. Preferably, the solute of the matrix solution includes sodium alginate an...

no. 3 approach

[0091] In the third embodiment of the present invention, a plugging product is provided, including the gel tissue plugging material according to the first embodiment, or the gel tissue plugging material obtained according to the preparation method of the gel tissue plugging material in the second embodiment. Glue tissue plugging material.

[0092] In the occlusive article of the present invention, optionally, there is a backing layer on the side of the substrate that does not have a wet-state adhesive layer, and a peelable layer on the wet-state adhesive layer. The present invention does not specifically limit the materials of the backing layer and the peelable layer, as long as they do not affect the function of the plugging product of the present application.

[0093] The occlusion product of the present invention can be used for hemostasis when tissue oozing, capillary bleeding, arteriolar bleeding, and lacunar oozing, and / or for hemostasis of burns, wounds, surgical wounds...

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Abstract

The invention provides a gel tissue plugging material and a preparation method thereof, and a plugging product. The gel tissue plugging material comprises: a matrix, wherein the matrix comprises a gellayer; and a wet-state adhesion layer on at least one surface of the matrix, wherein at least one surface of the matrix contacts an adhesion solution to obtain the wet-state adhesion layer, the adhesion solution contains an amino compound and a buffer liquid, and the amino compound is dissolved in the buffer liquid. According to the present invention, the gel tissue plugging material has advantages of excellent adhesion property, excellent bursting strength, suitable elongation at break and good elasticity, and can be effectively adhered to the surface of organisms or substantial organs so asto provide tissue plugging effect.

Description

technical field [0001] The invention relates to a gel tissue plugging material, a preparation method thereof and a plugging product, belonging to the field of medical implant materials. Background technique [0002] Tissue closure, such as: hemostasis closure, interstitial fluid leakage closure, etc., is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. [0003] At present, common hemostatic materials include microporous inorganic materials (zeolites), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tissue ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/04A61L24/10A61L24/00A61B17/12
CPCA61B17/12181A61L24/001A61L24/0015A61L24/0031A61L24/046A61L24/06A61L24/08A61L24/104C08L5/04C08L33/26C08L5/08C08L79/02
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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