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Application of biotransformation bear bile powder in preparation of antitussive medicine

A technology of biotransformation and bear bile powder, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2022-01-25
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even more serious is the long-term resistance of animal protection organizations at home and abroad to live bear bile harvesting, especially the recent "Guizhentang" incident that has once again aroused widespread concern from the international and domestic communities, which has greatly affected the production of domestic bear bile powder and the development of related industries. brought unprecedented resistance

Method used

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  • Application of biotransformation bear bile powder in preparation of antitussive medicine
  • Application of biotransformation bear bile powder in preparation of antitussive medicine
  • Application of biotransformation bear bile powder in preparation of antitussive medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0020] The preparation of embodiment 1 biotransformation bear bile powder

[0021] According to the preparation method in the invention patent application 201410588581.5, the biotransformation bear bile powder was prepared. The raw material poultry gall used in the present invention can be (and not limited to) chicken gall, duck gall, goose gall, ox gall, rabbit gall, dog gall, sheep gall, etc. The poultry gall powder described in the present invention can be (and not limited to) poultry gall powder such as chicken gall powder, duck gall powder, goose gall powder, ox gall powder, rabbit gall powder, dog gall powder, sheep gall powder, etc. One or more mixtures of them. Preferably, the main components and mass percentages of poultry bile powder are as follows: cholic acid: 40-65%, amino acid: 4-9%, trace element: 0.5-1%; wherein, the total cholic acid contains TCDCA, The TCDCA accounts for 40-50% by mass of poultry bile powder. In addition to the above main ingredients, poul...

Embodiment 2

[0034] Example 2 Antitussive Experiment: Effect on Ammonia-Induced Cough Model in Mice

[0035] 1. Materials

[0036] 1.1 Biotransformation bear bile powder (ABBP), provided by Shanghai Kaibao Pharmaceutical Co., Ltd., batch number: 20160801. Before use, the test drug was prepared with pure water at 2.5, 5.0, 10.0, and 20.0 mg / mL solutions, and it was used for clinical anthropomorphism The dosage is 0.3-1g / day, and the middle dosage is 0.01g / kg (70kg for a person).

[0037] 1.2 Ammonia water, Sinopharm Shanghai Chemical Reagent Company, batch number: 20160921.

[0038] 1.3 Animals: healthy ICR mice, male weight 20-22g, female weight 18-20g, provided by Shanghai Slack Experimental Animal Co., Ltd., certificate number: SCXK (Shanghai) 2012-0002, provided by Shanghai University of Traditional Chinese Medicine Animal Feeding management in the experimental center, license number: SYXK (Shanghai) 2014-0008, temperature 20-26°C, humidity 40-70%, 12h / 12h dark light cycle.

[0039] ...

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Abstract

The invention discloses the application of biotransformation bear bile powder in preparing antitussive medicine. The present invention studies the antitussive efficacy of the biotransformed bear bile powder, and the experimental results show that the biotransformed bear bile powder can prolong the cough incubation period and reduce the cough frequency of mice induced by ammonia water, thus revealing The application of biotransformed bear bile powder in the preparation of antitussive drugs was studied.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of biotransformed bear bile powder in the preparation of antitussive medicine. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. my country's annual output of bear bile powder is about 30 tons, which still cannot meet the needs of human health. At present, the contradiction between supply and demand of high-end bear bile powder is increasingly prominent and the market demand for bear bile powder for low-end raw materials continues to increase, which makes the price of bear bile powder rise stead...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/413A61K35/57A61P11/14
CPCA61P11/14A61K35/413A61K35/57
Inventor 张小利吴家胜杨莉马越鸣穆竟伟
Owner SHANGHAI KAIBAO PHARMA
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