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Preparation method and application of octacosanol-containing surfactant

A technology of stearyl alcohol and surfactant, which is applied in the field of bioengineering, can solve the problems of poor water solubility of higher fatty alcohols, affect flavor and sensory appearance, etc., achieve good uniformity, prevent cardiovascular and cerebrovascular diseases, and control blood pressure. Effect

Inactive Publication Date: 2019-01-04
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the poor water solubility of higher fatty alcohols, adding them to beverages, cosmetics, and foods will affect their flavor and sensory

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1) Add gamma-aminobutyric acid at a concentration of 0.1g / L and Tween 80 at a concentration of 0.2g / L to water, and stir at a high speed of 9000r / min to prepare a gamma-aminobutyric acid solution;

[0022] 2) Add octacosanol at a concentration of 0.2 g / L to the γ-aminobutyric acid solution prepared in step 1), add lipase at a concentration of 5000 U / ml, stir and react at 37°C for 8 hours to obtain γ-aminobutyric acid Octacosyl butyrate solution;

[0023] 3) Spray-dry the γ-aminobutyric acid octacosanol ester solution, spray drying parameters: the inlet temperature is 250°C, the air flow rate is 120kg dry air / h, and the solution flow rate is 2kg / h to obtain γ-aminobutyric acid Octacosyl Butyrate Powder.

Embodiment 2

[0025] 1) Add gamma-aminobutyric acid at a concentration of 0.1g / L and Tween 80 at a concentration of 0.2g / L to water, and stir at a high speed of 8000r / min to prepare a gamma-aminobutyric acid solution;

[0026] 2) Add octacosanol at a concentration of 0.1 g / L to the γ-aminobutyric acid solution prepared in step 1), add lipase at a concentration of 1000 U / ml, stir and react at 30°C for 4 hours to obtain γ-aminobutyric acid Octacosyl butyrate solution;

[0027] 3) Spray-dry the γ-aminobutyric acid octacosanol ester solution, the spray drying parameters: the inlet temperature is 200°C, the air flow rate is 100kg dry air / h, and the solution flow rate is 2kg / h to obtain γ-aminobutyric acid Octacosyl Butyrate Powder.

Embodiment 3

[0029] 1) Add gamma-aminobutyric acid at a concentration of 0.2g / L and Tween 80 at a concentration of 0.5g / L into water, and stir at a high speed of 10000r / min to prepare a gamma-aminobutyric acid solution;

[0030] 2) Add octacosanol at a concentration of 0.5 g / L to the γ-aminobutyric acid solution prepared in step 1), add lipase at a concentration of 5000 U / ml, stir and react at 40°C for 8 hours to obtain γ-aminobutyric acid Octacosyl butyrate solution;

[0031] 3) Spray-dry the γ-aminobutyric acid octacosanol ester solution, the spray drying parameters: the inlet temperature is 250°C, the air flow rate is 120kg dry air / h, and the solution flow rate is 3kg / h to obtain γ-aminobutyric acid Octacosyl Butyrate Powder.

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PUM

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Abstract

The invention discloses a preparation method and application of an octacosanol-containing surfactant. The preparation method includes: adding gamma-aminobutyric acid and Tween 80, stirring sufficiently to form a gamma-aminobutyric acid solution, sequentially adding octacosanol and lipoidase, stirring for reaction to obtain an octacosanol gamma-aminobutyrate solution, and spray-drying to obtain octacosanol gamma-aminobutyrate powder. The surfactant octacosanol gamma-aminobutyrate is prepared by synthesizing octacosanol and gamma-aminobutyric acid, the problem that higher aliphatic alcohol is low in water solubility is solved, no flavor and sense problems will be caused when the surfactant is added into food, cosmetics and beverages, and the surfactant is high in uniformity; the gamma-aminobutyric acid and octacosanol have complementary and synergistic effect on body regulation and can better control blood pressure, stop thrombosis and effectively prevent cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a preparation method and application of a surfactant containing octacosanol, belonging to the field of bioengineering. Background technique [0002] Octacosanol is a biologically active substance. Its main physiological effects include: 1) Improve endurance, energy and physical strength; 2) Shorten muscle nerve reaction time and improve response sensitivity; 3) Promote hormone function and relieve muscle pain; 4) Improve myocardial function and reduce systolic blood pressure; 5) Improve the body's basal metabolic rate. Octacosanol can be used to treat osteoporosis with hypercalcemia, treat hypercholesterolemia and hyperlipoproteinemia diseases, and stimulate the sexual behavior of animals and humans. Cosmetics containing octacosanol can promote skin blood circulation and Activate cells, have anti-inflammatory, prevent and treat skin diseases and other effects. Moreover, octacosanol is extremely safe and is used in a small amo...

Claims

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Application Information

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IPC IPC(8): C12P7/62A61K8/44A61K8/34A61Q19/00A23L29/00A23L33/175
CPCA23V2002/00A61K8/342A61K8/44A61K2800/10A61K2800/596A61Q19/00A23L29/035A23L33/175C12P7/62A23V2250/038
Inventor 汤佳鹏葛彦朱俐
Owner NANTONG UNIVERSITY
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