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High-purity bamboo leaf carbon glycosyl flavone nanoparticle as well as preparation method and application thereof

A carbon glycoside flavonoid and nanoparticle technology, applied in the field of daily chemicals, can solve the problems of reduced water solubility, limited application, poor water solubility, etc., and achieve the effects of delaying skin aging, uniform particle size, and stable quality

Active Publication Date: 2019-01-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The size of the β-cyclodextrin cavity is moderate, but the water solubility is poor. The solubility in 100mL water (25°C) is only 1.85g, while that of α-cyclodextrin is 14.5g, and that of γ-cyclodextrin is 23.3g. This is because C in β-cyclodextrin molecule 2 and C 3 It is easy to form intramolecular hydrogen bonds between hydroxyl groups, which reduces water solubility and limits its application in aqueous solutions; secondly, the molecular pores of β-cyclodextrin are relatively small, and it can only include small molecular guest substances

Method used

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  • High-purity bamboo leaf carbon glycosyl flavone nanoparticle as well as preparation method and application thereof
  • High-purity bamboo leaf carbon glycosyl flavone nanoparticle as well as preparation method and application thereof
  • High-purity bamboo leaf carbon glycosyl flavone nanoparticle as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1, the preparation of a kind of high-purity bamboo glucoside flavone nanoparticles

[0077] 1), weigh 1g L - Dissolve BLF in 10mL warm water (water at 30°C), fully dissolve (ultrasound-assisted dissolution at room temperature can be used), centrifuge (5000rpm, 5min), take the supernatant and put it on the column (100-200 mesh polyamide resin 200g), Use 1600 mL of 20%, 30%, 40%, and 50% ethanol to elute in sequence, and collect the 40%-50% ethanol eluate. Concentrate the eluate from 40% to 50% ethanol under reduced pressure (0.08Mpa pressure) to 5% to 8% of the original volume, and then go to C 18 Reversed phase column (YMC C 18 C of 50 μm chromatography packing material 18 Liquid chromatography column), eluted with 800mL of 15%, 25%, 30%, 35%, 40%, 50% ethanol successively, collected the eluate obtained respectively, and detected by high performance liquid chromatography, the chromatographic condition ODS-C 18 (250mm×4.6mm, 5μm), the mobile phase is metha...

Embodiment 2

[0085] Embodiment 2, a kind of preparation method of high-purity bamboo glycoside flavonoid nanoparticles

[0086] Step 1)~step 4) with embodiment 1;

[0087] 5) Under the condition of low-speed magnetic stirring, add 6mg of γ-cyclodextrin (γ-CD) to step 4) H -BLFnd, and stirred until the γ-CD is completely dissolved, frozen in an ultra-low temperature refrigerator (-80°C) for 24h, and then freeze-dried at -50°C and a vacuum of 9-21Pa for 48h to obtain high-purity bamboo leaf carbon glycoside flavone nano-frozen Dry powder (denoted as H -BLFnp②).

[0088] This high-purity bamboo leaf carbon glycoside flavone nano freeze-dried powder ( H - Moisture content of BLFnp ①) ≤ 5%.

Embodiment 3

[0089] Embodiment 3, a kind of preparation method of high-purity bamboo leaf carbon glycoside flavonoid nanoparticles:

[0090] Step 1)~step 4) with embodiment 1;

[0091] 5) Under the condition of low-speed magnetic stirring, add 6 mg of α-cyclodextrin (α-CD) to the obtained product in step 4) H -BLFnd, and stirred until α-CD is completely dissolved, frozen in an ultra-low temperature refrigerator (-80°C) for 24 hours, and then freeze-dried at -50°C and vacuum degree of 9-21Pa for 48 hours to obtain high-purity bamboo leaf carbon glycoside flavone nano-frozen Dry powder (denoted as H -BLFnp③).

[0092] This high-purity bamboo leaf carbon glycoside flavone nano freeze-dried powder ( H - Moisture content of BLFnp ①) ≤ 5%.

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Abstract

The invention belongs to the field of daily chemicals and relates to high-purity bamboo leaf carbon glycosyl flavone nanparticles as well as a preparation method and application thereof as a skincarefunctional factor in cosmetics. Specifically, the invention discloses the high-purity bamboo leaf carbon glycosyl flavone nanparticles which consist of the following effective components in percentageby mass: 4-10% of high-purity bamboo leaf carbon glycosyl flavones, 65-81% of common turnip polysaccharide and 10-25% of epsilon-polylysine. The invention further discloses a preparation method of the high-purity bamboo leaf carbon glycosyl flavone nanparticles. The invention further discloses application of the high-purity bamboo leaf carbon glycosyl flavone nanparticles. The high-purity bambooleaf carbon glycosyl flavone nanparticles are a natural, safe and efficient skincare functional factor and have excellent effects of whitening skin, moisturizing skin and retarding aging.

Description

technical field [0001] The invention belongs to the field of daily chemicals. Specifically, it relates to a high-purity bamboo glycoside flavonoid nanoparticle, its preparation method and its use in cosmetics as a skin care functional factor. Background technique [0002] The skin is in direct contact with the outside world. It is the first barrier of the body and an important part of maintaining human life and health. However, it is extremely susceptible to damage caused by environmental factors. In addition to age factors, stress response, environmental pollution, sunlight and Ultraviolet radiation is an important cause of skin damage and aging. With the improvement of the quality of life brought about by economic development, everyone hopes to have healthy, beautiful, and young skin. Therefore, it is of great significance to study the skin care functional factors that help maintain skin moisture, whiten and smooth skin, and delay skin aging. [0003] In the field of bea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/88A61K8/73A61K8/49A61K8/02A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/0245A61K8/498A61K8/73A61K8/738A61K8/88A61K8/9789A61K8/9794A61K2800/413A61K2800/56A61K2800/57A61Q19/00A61Q19/02A61Q19/08
Inventor 张英张宇靖周沫希韩建欣
Owner ZHEJIANG UNIV
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