A composition for treating acne and an application thereof

Abstract

The invention belongs to the technical field of pharmaceutical preparations, in particular to a composition for treating acne and an application thereof. The composition for treating acne comprises the following components by weight: isotretinoin 10-30 part, erythromycin 110-125 parts, vitamin B6 10-30 parts, and zinc gluconate 60-80 parts. The composition for treating acne has the advantages of small dosage, long course of treatment, few adverse reactions, good compliance of the patient, and can be taken according to the course of treatment, so that the etiology can be continuously cleared and the drug effect can be exerted for a long time; the disease does not relapse after healing, and good news is brought for the patients who are troubled by acne.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a composition for treating acne and its application. Background technique [0002] Acne (commonly known as whelk), with the improvement of people's living standards, the pace of life is accelerated, the diet changes (too spicy, greasy, too much intake of desserts and other foods), irregular work and rest, and environmental climate changes. In addition, various pathogenic factors such as hormone imbalance in the body, genetics, etc. act on the sebaceous glands of the human body's head, face, chest and back skin, increasing gland secretion, keratin embolism, poor discharge, and concurrent Propionibacterium acnes infection, which leads to the occurrence of this disease. [0003] The concept, acne, is a chronic inflammatory skin disease of the pilosebaceous unit. It mainly occurs during puberty, so it is commonly called (acne), and both men and women c...

AI Technical Summary

Problems solved by technology

[0005] At present, the main shortcomings of western medicine and western medicine in the treatment of acne are: 1) simple changes in diet and work and rest habits are used as general treatment, but most of them have no significant effect; 2) antibiotics are mostly tetracyclines, macrolides or nitroimidazoles Mainly, their common disadvantages are large dosage, long course of treatment, easy drug resistance, easy damage to liver and kidney function, gastrointestinal tract, and damage to human hematopoietic system, long-term use can cause flora imbalance (superinfection), etc.; 3) The curative effect of vitamins alone is not obvious, and they are only used as adjuvant therapy; 4) Oral preparations of vitamin A acids are often used in clinical practice. The dosage is too large, and the course of treatment is too long. , pain, rash, secondary infection, rhabdomyolysis, tendon injury, etc.; 5) Use of some endocrine preparations such as ①The risk of thromboembolism if the estrogen treatment is too long, female patients can cause menstrual disorders, etc.; ②Sugar Excessive dosage of corticosteroids or prolonged treatment can lead to gastric ulcer, gastric bleeding, aggravated infection, osteoporosis, fracture, etc.; Higher level, antibiotics for external use, long-term use can cause skin superinfection, skin irritation, skin allergies, drug resistance, etc.; ④Sulfur creams have little curative effect when used alone; ⑤The curative effect of benzoyl peroxide drugs is fair , it needs long-term application to be effective, but the skin is highly irritating, which can easily cause skin burning, pain, erythema, peeling, and hair whitening. The patient's compliance is poor, and the inability to adhere to medication is also its disadvantage; ⑥ Tretinoin external rubbing Pills with about the same downsides as benzoyl peroxide

In addition to western medicine and western medicine, there are also phototherapy, facial mask, etc. in the direction of medical beauty, which are only used as general treatments. They are not effective for moderate to severe acne alone, and oral medicine and other treatment methods are needed to be curative.

[0006] At present, the shortcomings of traditional Chinese medicine in the treatment of acne are mainly as follows: 1) the course of treatment of oral medicine decoction is generally long, decocting is time-consuming and laborious, and it is difficult to be effective in the short term; 3) The clinical efficacy lacks evidence-based medical evidence, and the drug is mostly used empirically; 4) Due to the inconvenience of carrying and taking, the patient's compliance is poor, and the long-term medication cannot be adhered to, so the curative effect is unsatisfactory; 5) Traditional Chinese medicine for external use is also mostly empirical medicine of traditional Chinese medicine, and there is also a lack of clinical data and standards. It is effective for some, and the treatment of the disease with external Chinese medicine can only be clinically relieved, and it is extremely difficult to cure

[0007] In view of the high incidence of this disease, low cure rate, long course of disease, easy recurrence, and easy to leave scars after healing, as well as the respective advantages and disadvantages of the above-mentioned Chinese and Western medicines, the applicant of the present invention rigorously combines Chinese and Western medicines and proposes a A new composition for effectively treating acne. It has been proved by years of clinical outpatient treatment that the composition can treat various types of acne, especially for moderate to severe acne, or stubborn and unhealed cases.