Nano chitin-pva hydrogel and its preparation method and application
A nano-chitin and hydrogel technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of unsustainable development, complicated preparation process, and high energy consumption. problem, to achieve good delivery effect, simple preparation process, and low energy consumption
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[0045] According to the first aspect of the present invention, the present invention provides a kind of preparation method of nano chitin-PVA hydrogel, comprises the steps:
[0046] (a) mixing the nano-chitin dispersion liquid with the polyvinyl alcohol solution to cause a physical crosslinking reaction to obtain a mixed dispersion liquid after the physical crosslinking reaction;
[0047] (b) Adding a cross-linking agent to the mixed dispersion after the physical cross-linking reaction to cause a chemical cross-linking reaction to obtain nano-chitin-PVA hydrogel.
[0048] The preparation method of the nano-chitin-PVA hydrogel provided by the invention adopts the mixing of the nano-chitin dispersion liquid and the polyvinyl alcohol solution, a physical cross-linking reaction occurs, and then the mixed dispersion liquid after the physical cross-linking reaction is mixed with a cross-linking agent , a chemical cross-linking reaction occurs to obtain a nano-chitin-PVA hydrogel, the ...
Embodiment 1
[0084] The present embodiment provides a kind of preparation method of nano-chitin dispersion liquid, comprises the following steps:
[0085] Soak 20g of discarded shrimp shells in 1mol / L sodium hydroxide solution, stir mechanically for 2h, remove residual protein, and wash with deionized water until neutral; then soak in 1mol / L hydrochloric acid, stir mechanically for 2h, remove minerals, And wash with deionized water to neutral; finally soak in 0.8mol / L sodium chlorite solution for 2h, bleach the treated chitin; dry after bleaching; soak the dried chitin in 30wt% hydrogen Carry out partial deacetylation treatment in sodium oxide solution at 90°C for 3 hours, add 5g of sodium borohydride at the same time, the deacetylation rate is 45%, then add acetic acid to adjust the pH to 3.5 to obtain a chitin suspension, and pass the chitin suspension through high pressure Homogenize with a homogenizer to obtain a nano-chitin dispersion, measure the solid content of the nano-chitin disp...
Embodiment 2
[0087] The present embodiment provides a kind of preparation method of nano chitin-PVA hydrogel, comprises the steps:
[0088] The nano-chitin dispersion prepared in Example 1 and 10wt% polyvinyl alcohol AH-26 solution were fully stirred and mixed evenly at room temperature, and the mass ratio of nano-chitin dispersion to polyvinyl alcohol AH-26 solution was 9: 1. Then mechanically stir in an oil bath at 70°C for 2 hours to cause a physical crosslinking reaction to obtain a mixed dispersion after the physical crosslinking reaction;
[0089] After the physical cross-linking reaction, the mixed dispersion liquid was left to cool to normal temperature, and the pH was adjusted to 1.5 with HCl solution, and then 10 g of 0.3 wt% glutaraldehyde solution was added, magnetically stirred evenly and a chemical cross-linking reaction occurred to obtain nano-chitin -PVA hydrogel, the formed nano-chitin-PVA hydrogel is repeatedly washed with deionized water to remove the residual cross-link...
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