Method and DNA methylation marker for predicting reduction risk of weightless bone loss carboxyterrninal propeptide of type I pmcollagen (PICP)

Abstract

The invention provides a DNA methylation marker for predicting the reduction risk of weightless bone loss carboxyterrninal propeptide of type I pmcollagen (PICP). The DNA methylation marker includes one or more genes, and the annotation information of gene loci is shown in Table 3. The invention also provides a corresponding detection method. A result of the studying of the DNA methylation level of blood cells and the bone mineral density index (PICP) of serum shows that the DNA methylation level of the blood cells is detected to realize the predication of the individual difference in the decrease of the PICP of a weightless human body, so the method and the marker can be used to screen individuals having high tolerance to weight loss conditions or scientifically study the change of the PICP. A DNA methylation locus set which has a predictive function on the reduction risk of the PICP of the weightless human body is provided and is highly correlated with human body bone metabolism.

Description

technical field [0001] The invention belongs to the technical field of physiology, relates to physiological changes after a period of time in weightless environmental conditions, and specifically relates to a method and a DNA methylation marker for predicting the risk of weightless bone loss type I procollagen carboxyl-terminal propeptide PICP decline. Background technique [0002] Carboxyterrninal propeptide of type Ipmcollagen (PICP) is the only collagen in bone tissue, accounting for more than 90% of bone matrix. The level of carboxy-terminal propeptide of type I procollagen in serum is a specific index reflecting osteoblast activity and bone formation and reflecting the synthesis rate of type I collagen. [0003] Normal bone undergoes continuous remodeling in which bone degradation or resorption is balanced by bone formation. This process is necessary to maintain bone health. If the processes become uncoupled, and the rate of resorption exceeds the rate of formation, t...

AI Technical Summary

Problems solved by technology

If the processes become uncoupled, and the rate of resorption exceeds the rate of formation, the resulting bone loss can lead to osteoporosis and thus a higher susceptibility to fracture

Weightlessness bone loss is a long-term, continuous and progressive change. The result of its development will lead to osteoporosis, soft tissue calcification, kidney stones and other pathological phenomena, and even gravity re-adaptation disorder, which will seriously affect the astronauts' health and well-being. work efficiency

Existing methods are difficult to prevent and delay spatial bone loss

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