Hydrophobic three-dimensional porous material, preparation method and application thereof and blood storage bag

A three-dimensional porous and hydrophobic technology, applied in the field of medical equipment, can solve the problems of high requirements for preparation technology, harm of organic solvents, expensive preparation equipment, etc., and achieves the effects of simple operation, reduced carbon dioxide partial pressure, and low cost.

Inactive Publication Date: 2019-02-05
韩昱苏 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of potential hazards caused by residual organic solvents, expensive preparation equipment, harsh preparation conditions, high preparation technical requirements, and complicated and cumbersome processes in the preparation methods of hydrophobic three-dimensional porous structures in the prior art, and provide A preparation method of a hydrophobic three-dimensional porous material, a hydrophobic three-dimensional porous material prepared by the preparation method, an application of the hydrophobic three-dimensional porous material and a blood storage bag

Method used

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  • Hydrophobic three-dimensional porous material, preparation method and application thereof and blood storage bag
  • Hydrophobic three-dimensional porous material, preparation method and application thereof and blood storage bag
  • Hydrophobic three-dimensional porous material, preparation method and application thereof and blood storage bag

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preparation example Construction

[0028] A method for preparing a hydrophobic three-dimensional porous material, the method comprising:

[0029] (1) Prepare a porous structure sugar template by using water-soluble sugar;

[0030] (2) Pouring polydimethylsiloxane into the sugar template with a porous structure and solidifying it;

[0031] (3) removing the porous structure sugar template in the solid material obtained in step (2).

[0032] According to the present invention, preferably, the solubility of the water-soluble sugar in water at 25° C. is 1.9-2.1 g sugar / g water, more preferably 1.95-2.05 g sugar / g water.

[0033] According to the present invention, preferably the water-soluble sugar is sucrose. In order to further control the pore structure of the hydrophobic three-dimensional porous material, preferably the water-soluble sugar contains coarse sugar and raffinose.

[0034] In the present invention, preferably, the particle size of the coarse granulated sugar is 300-1250 μm, and the particle size o...

Embodiment approach

[0043] According to a preferred embodiment of the present invention, the contacting is carried out under the second vacuum condition, the contacting time is 7-17 hours, and the contacting temperature is 10-20°C.

[0044] Among the present invention, the first vacuum is used to extract the air bubbles in the polydimethylsiloxane and curing agent; the second vacuum is used to remove the air bubbles in the porous structure sugar template, and is convenient for the polydimethylsiloxane to enter In the pores of the porous structure sugar template.

[0045] According to the present invention, preferably, the mass ratio of polydimethylsiloxane to water-soluble sugar is 1-3:1, more preferably 1.5-2.5:1, even more preferably 1.5-2:1. Adopting the preferred embodiment of the present invention is more conducive to the formation of irregular pore structures in hydrophobic three-dimensional porous materials.

[0046]The specific implementation of the step (2) of the present invention may ...

preparation example 1

[0077] (1) Preparation of porous structure sugar template

[0078] Take 30g of coarse granulated sugar and 70g of cotton white sugar and mix in a beaker, add deionized water according to the ratio of 100g of water-soluble sugar (the total mass of coarse granulated sugar and cotton white sugar) to 1mL of deionized water and mix evenly; pour the mixed material into the mold (Self-made Z-type PMMA mold, specific as figure 2 The shape of the filter element in the blood storage bag shown, the same below), and press the mold tightly; put the mold in an oven, and heat it at 80°C for 1 hour; after cooling to room temperature, put the mold containing the porous sugar template in a vacuum in a vacuum device;

[0079](2) Infusion of polydimethylsiloxane

[0080] Polydimethylsiloxane (150g) is mixed with curing agent in a mass ratio of 10:1, and then vacuumized for 30min to remove air bubbles to obtain a mixture, which is all poured into a mold filled with a porous structure sugar temp...

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Abstract

The invention relates to the field of medical equipment, and discloses a hydrophobic three-dimensional porous material, a preparation method and application thereof and a blood storage bag. The preparation method of the hydrophobic three-dimensional porous material comprises the steps that (1) a porous structure sugar template is prepared from water-soluble sugar; (2) polydimethylsiloxane is poured into the porous structure sugar template and solidified; and (3) the porous structure sugar template in a solid material obtained in step (2) is removed. The preparation method of the hydrophobic three-dimensional porous material is easy to operate and low in cost, and no organic solvent residue exists in the prepared hydrophobic three-dimensional porous material; and the hydrophobic three-dimensional porous material prepared through the preparation method of the hydrophobic three-dimensional porous material is of an irregular pore structure and is used for remarkably increasing the oxygen partial pressure of a blood sample in the blood storage bag, decreasing the carbon dioxide partial pressure and improving deformability of erythrocytes.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a hydrophobic three-dimensional porous material, its preparation method and application, and a blood storage bag. Background technique [0002] Hydrophobic three-dimensional porous structures widely exist in nature and living organisms, and have the characteristics of high specific surface area. The hydrophobic three-dimensional porous structure is an important way to connect the inside and outside and exchange matter and energy. It has great application prospects in bioreactors, dielectrics, sensors, drug delivery, material separation, catalysis, etc. [0003] The preparation of classic hydrophobic three-dimensional porous materials often needs to be made of glass, TiO 2 Microspheres made of materials such as polymers or polymers accumulate and communicate at high temperatures (such as glass: 500-1600°C) to form a template, then fill the material, solidify, and finally dissolv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26B01D29/56A61J1/10A61J1/14C08L83/04
CPCA61J1/10A61J1/1443A61J1/1468B01D29/56C08J9/26C08J2201/0422C08J2383/04
Inventor 韩昱苏刘景华闻达
Owner 韩昱苏
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