Anti-tumor experimental animal model and construction method thereof

An experimental animal and construction method technology, applied in the field of anti-tumor experimental animal model and its construction, can solve the problems of unconvincing verification effect, long process time, and death of experimental animals.

Inactive Publication Date: 2019-02-15
胡学东
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] To sum up, the problems existing in the prior art are: traditional anti-tumor animal models need to culture a variety of tumor cells, and then transplant them into animals to allow them to spread; group verificat

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  • Anti-tumor experimental animal model and construction method thereof
  • Anti-tumor experimental animal model and construction method thereof

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Embodiment Construction

[0016] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0017] For traditional anti-tumor animal models, it takes a long time to cultivate a variety of tumor cells, and the verification effect is not convincing; the animal experimental model of the present invention directly injects tumors into experimental animals under sterile conditions. Bacterial dilutions were used to grow tumors in animals, and the verification process was relatively short. The inhibition rate was calculated by weighing tumor weights, and the verification effect was convincing.

[0018] The application principle of the present invention will be described in detail below in conjunction with the accompanying...

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Abstract

The invention belongs to the technical field of vertebrate breeding, and discloses an anti-tumor experimental animal model and a construction method thereof. The right armpits of mice or rats for experiments are taken for subcutaneous vaccination of a mouse or rat tumor sterile diluent according to the sterile operation, and weighing and grouping are performed after 24 hours; weighing is performedafter 24 hours, random grouping is performed, 10 mice or rats fall into one group, 20 mg/kgi.p of CTX is applied every day, and intragastric administration is performed on the other groups; a constant amount of distilled water is given to a model control group, the equal amount of normal saline is inoculated on normal animals which are animals with no inoculated tumor as ten animals as a fake inoculation group, the constant volume of distilled water is fed every day to the normal animals as a normal control group, and the water is fed every day for 7 days. According to the animal experimentalmodel, a tumor sterile diluent is directly injected into experimental animals under the sterile condition, tumors grow inside the animals, the verification process is short, and by weighing the tumorweight and calculating the inhibition rate, the verification effect is convictive.

Description

technical field [0001] The invention belongs to the technical field of cultured vertebrates, and in particular relates to an anti-tumor experimental animal model and a construction method thereof. Background technique [0002] At present, the commonly used prior art in the industry is as follows: cancer is a common and frequently-occurring disease in human beings, and it has become a synonym for death due to its high mortality rate. Cancer is a serious threat to human health and life. All countries in the world have invested a lot of manpower and material resources to attack cancer in an all-round way. Studies have shown that traditional Chinese medicine not only has a good curative effect on cancer treatment, but also can reduce side effects and disease recurrence rate, can effectively prolong the survival period of patients and improve the quality of life of patients, and stabilize or shrink tumors to a certain extent. Therefore, traditional Chinese medicine and the combi...

Claims

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Application Information

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IPC IPC(8): A01K67/02A61K35/13
CPCA01K67/02A01K2227/105A01K2267/03A61K35/13
Inventor 胡学东
Owner 胡学东
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