Application of metformin in treatment of autoimmune hepatitis of mouse

An autoimmune and metformin technology, applied in the medical field, can solve problems such as autoimmune hepatitis that has not been studied, achieve the effect of improving liver cell function, promoting liver cell regeneration, and being easy to carry and take

Active Publication Date: 2019-02-15
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

But whether metformin can improve autoimmune hepatitis has not been studied

Method used

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  • Application of metformin in treatment of autoimmune hepatitis of mouse
  • Application of metformin in treatment of autoimmune hepatitis of mouse
  • Application of metformin in treatment of autoimmune hepatitis of mouse

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Embodiment Construction

[0017] The application of metformin in the treatment of autoimmune hepatitis in mice comprises the following steps, (1) establishment of the model, making the mice have autoimmune hepatitis; (2) treatment, giving the mice with autoimmune hepatitis after step 1 The drug is given by intragastric administration of metformin solution dissolved in normal saline, the final concentration of metformin in normal saline is 6-10 mg / ml, and the dosage of mice is to give metformin to each mouse every day. 150-250mg / kg.d.

[0018] In the embodiment of the present invention, the model was established: on the first day and the seventh day of modeling, the mice were given intraperitoneal injection of 10% chloral hydrate, and after the mice were completely anesthetized, the mice were cut open with surgical scissors. Abdominal skin and peritoneum, expose the portal vein, insert the fine infusion needle into the portal vein, fix the infusion needle after confirming successful insertion, perfuse w...

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Abstract

The invention relates to the field of medicine, in particular to an application of metformin in treatment of autoimmune hepatitis of a mouse. According to the technical scheme, the application of metformin in treatment of autoimmune hepatitis of the mouse is characterized by comprising steps as follows: (1), model establishment: the mouse is infected with autoimmune hepatitis; (2), treatment: a drug is administrated to the mouse with autoimmune hepatitis in step one, the administration mode is intragastric administration of liquid metformin dissolved in normal saline, final concentration of metformin in normal saline is 6-10 mg/ml, and dosage of administration for each mouse is 150-250 mg/kg.d every day. With the adoption of the scheme, metformin has a quite definite curative effect on autoimmune hepatitis of the mouse.

Description

technical field [0001] The invention relates to a medical field, in particular to the application of metformin in the treatment of autoimmune hepatitis in mice. Background technique [0002] Autoimmune hepatitis: Autoimmune hepatitis (AIH) is a chronic hepatitis mediated by an autoimmune response against hepatocyte antigens. Clinically, it is characterized by elevated serum transaminases, multiple autoantibody positivity, high Gammaglobulinemia and interface hepatitis are characteristic. The pathogenesis of AIH has not been fully clarified, and scholars have put forward a variety of hypotheses, such as environmental factors triggering the immune response to autoantigens in the liver, impaired immune regulation, intestinal flora disturbance, and increased intestinal permeability in genetically susceptible individuals. Recent studies have found that intestinal inflammation, intestinal flora disorder, and Treg / Th17 cell balance disruption may be one of the main mechanisms for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P1/16
CPCA61K31/155A61P1/16
Inventor 陈永平潘彤彤许烂漫吴发玲陈达之
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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