Application of metformin in the treatment of autoimmune hepatitis in mice

An autoimmune, metformin technology, applied in the medical field, can solve the problems of unresearched autoimmune hepatitis, and achieve the effects of improving liver cell function, regulating intestinal microecology, and stable properties.

Active Publication Date: 2021-08-10
THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But whether metformin can improve autoimmune hepatitis has not been studied

Method used

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  • Application of metformin in the treatment of autoimmune hepatitis in mice
  • Application of metformin in the treatment of autoimmune hepatitis in mice
  • Application of metformin in the treatment of autoimmune hepatitis in mice

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Embodiment Construction

[0017] The application of metformin in the treatment of autoimmune hepatitis in mice comprises the following steps, (1) establishment of the model, making the mice have autoimmune hepatitis; (2) treatment, giving the mice with autoimmune hepatitis after step 1 The drug is given by intragastric administration of metformin solution dissolved in normal saline, the final concentration of metformin in normal saline is 6-10 mg / ml, and the dosage of mice is to give metformin to each mouse every day. 150-250mg / kg.d.

[0018] In the embodiment of the present invention, the model was established: on the first day and the seventh day of modeling, the mice were given intraperitoneal injection of 10% chloral hydrate, and after the mice were completely anesthetized, the mice were cut open with surgical scissors. Abdominal skin and peritoneum, expose the portal vein, insert the fine infusion needle into the portal vein, fix the infusion needle after confirming successful insertion, perfuse w...

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Abstract

The invention relates to a medical field, in particular to the application of metformin in the treatment of autoimmune hepatitis in mice. The technical solution adopted in the present invention is: the application of metformin in the treatment of autoimmune hepatitis in mice, which is characterized in that it includes the following steps: (1) establishment of a model to make mice have autoimmune hepatitis (2) treatment, the steps One after administration to mice with autoimmune hepatitis, the way of administration is to give metformin liquid dissolved in normal saline, the final concentration of metformin in normal saline is 6-10mg / ml, the mouse's The dosage is 150-250 mg / kg.d of metformin per mouse per day. By adopting the above scheme, the present invention mainly realizes that metformin has a very clear curative effect in treating autoimmune hepatitis in mice.

Description

technical field [0001] The invention relates to a medical field, in particular to the application of metformin in the treatment of autoimmune hepatitis in mice. Background technique [0002] Autoimmune hepatitis: Autoimmune hepatitis (AIH) is a chronic hepatitis mediated by an autoimmune response against hepatocyte antigens. Clinically, it is characterized by elevated serum transaminases, multiple autoantibody positivity, high Gammaglobulinemia and interface hepatitis are characteristic. The pathogenesis of AIH has not been fully clarified, and scholars have put forward a variety of hypotheses, such as environmental factors triggering the immune response to autoantigens in the liver, impaired immune regulation, intestinal flora disturbance, and increased intestinal permeability in genetically susceptible individuals. Recent studies have found that intestinal inflammation, intestinal flora disorder, and Treg / Th17 cell balance disruption may be one of the main mechanisms for ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/155A61P1/16
CPCA61K31/155A61P1/16
Inventor 陈永平潘彤彤许烂漫吴发玲陈达之
Owner THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
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