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Pharmaceutical composition containing mycophenolate mofetil

A technology of mycophenolate mofetil and its composition, which is applied in the field of pharmaceutical preparations, can solve the problems of liver and kidney damage, large toxic and side effects, and unbearable for patients, and achieve the goal of reducing dosage, reducing toxic and side effects, and synergistic effect of curative effect Effect

Inactive Publication Date: 2019-02-22
WUXI FORTUNE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the relatively large toxic and side effects of these drugs, for patients who receive immunosuppressant therapy after organ transplantation using mycophenolate mofetil alone in the prior art, it is easy to induce infection, tumor, etc., and cause damage to the liver and kidney , and the long-term application of these drugs is expensive and difficult for patients to bear

Method used

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  • Pharmaceutical composition containing mycophenolate mofetil
  • Pharmaceutical composition containing mycophenolate mofetil
  • Pharmaceutical composition containing mycophenolate mofetil

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The dosage form of a pharmaceutical composition containing mycophenolate mofetil disclosed in this example is a method for preparing capsules, which is prepared from the following components in parts by weight per 100 g:

[0023]

[0024] In this embodiment, the preparation method of the pharmaceutical composition containing mycophenolate mofetil comprises the following steps:

[0025] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 70-mesh sieve respectively for subsequent use.

[0026] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0027] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0028] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into capsu...

Embodiment 2

[0030] This example discloses another preparation method of a pharmaceutical composition containing mycophenolate mofetil in the form of a capsule, which is prepared from the following components in parts by weight per 100 g:

[0031]

[0032] In this embodiment, the preparation method of the pharmaceutical composition containing mycophenolate mofetil comprises the following steps:

[0033] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 70-mesh sieve respectively for subsequent use.

[0034] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0035] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0036] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into capsule...

Embodiment 3

[0038] The preparation method of another pharmaceutical composition containing mycophenolate mofetil disclosed in this example is a capsule, per 100g, which is mainly made of the following main ingredients and auxiliary materials:

[0039]

[0040] In this embodiment, the preparation method of the pharmaceutical composition containing mycophenolate mofetil comprises the following steps:

[0041] Step (1), weighing the raw and auxiliary materials of the above-mentioned prescription amount, passing through a 70-mesh sieve respectively for subsequent use.

[0042] Step (2), putting the sieved raw and auxiliary materials into a wet granulator, premixing, spraying an appropriate amount of purified water to granulate, drying, and sizing.

[0043] Step (3), adding the granulated material into the mixer, adding lubricant, and mixing evenly.

[0044] Step (4), using No. 1 capsule mold on the capsule filling machine to prepare the blended material and hollow gelatin capsules into ca...

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Abstract

The invention discloses a pharmaceutical composition containing mycophenolate mofetil. The pharmaceutical composition is prepared from the following components in parts by weight: 5-80 parts of the mycophenolate mofetil, 5-50 parts of a second- type of therapeutic agent, 5-30 parts of a filler, 0.5-10 parts of an adhesive, 0.1-10 parts of a disintegrating agent, 0.5-5 parts of a lubricating agentand 1-20 parts of solubilizer. According to the pharmaceutical composition containing the mycophenolate mofetil, the application dosage of the mycophenolate mofetil is reduceddecreased, the toxic andside effects are reduced, and meanwhile, the pharmaceutical composition has the synergistic effect on efficacy of different drugs.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing mycophenolate mofetil. Background technique [0002] Organ transplantation has become an effective means of modern medicine to treat end-stage organ failure, but the success rate of organ transplantation is seriously affected by the rejection of transplanted organs. In recent years, domestic and foreign scholars have conducted a lot of research on drugs against transplant rejection, including Cyclosporin A, FK506, mycophenolate mofetil (Xiaozhi), specific monoclonal antibodies, etc. [0003] Mycophenolate mofetil (MMF for short) is a 2-ethyl ester derivative of mycophenolic acid (MPA). MPA is an efficient, selective, non-competitive and reversible A hydrogenase (IMPDH) inhibitor that inhibits the classical synthesis pathway of guanine nucleotides. MPA has a highly selective effect on lymphocytes. [0004] Due to the r...

Claims

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Application Information

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IPC IPC(8): A61K36/40A61K36/48A61K36/59A61K36/9066A61K31/4375A61K31/5377A61K36/076A61K36/236A61K36/268A61K36/37A61P39/06
CPCA61K31/4375A61K31/5377A61K36/076A61K36/236A61K36/268A61K36/37A61K36/40A61K36/48A61K36/59A61K36/9066A61P39/06A61K2300/00
Inventor 韩小霜郁晨燕薛丹露李标有张峰
Owner WUXI FORTUNE PHARMA
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