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Device for realizing internal field intensity focusing of non-metallic effector in irradiation cavity

An effector, non-metallic technology, applied in radiation therapy, treatment, etc., can solve the problems that the effective absorption of drugs is difficult to achieve, and the effective implementation of drug treatment for brain diseases is restricted.

Active Publication Date: 2019-02-22
NORTHWEST INST OF NUCLEAR TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, for central nervous system diseases, the effective absorption of drugs is difficult to achieve due to the existence of BBB, which seriously restricts the effective implementation of drug therapy for brain diseases.

Method used

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  • Device for realizing internal field intensity focusing of non-metallic effector in irradiation cavity

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Embodiment Construction

[0019] Below in conjunction with accompanying drawing, the present invention is further described through embodiment.

[0020] On the one hand, the present invention uses an insulating medium with a relative permittivity smaller than that of the non-metallic effector in the irradiation chamber to partially fill the surrounding space near the effector, that is, the relative permittivity of the medium used for filling is greater than that of air. The dielectric constant, but less than that of the effector. When the electromagnetic wave starts from the excitation source, passes through the front transition section of the irradiation cavity to generate an approximately uniform spherical wave, and then reaches the working space of the irradiation cavity, a vertically polarized uniform field is formed in the working space. When the uniform field passes through When penetrating the filled medium and reaching the surface of the effect object, due to the slow increase of the relative p...

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Abstract

The invention provides a device for realizing the internal field intensity focusing of a non-metallic effector in an irradiation cavity so that the local focusing of the field strength of the effectorin the irradiation cavity can be improved efficiently. The device comprises an irradiation cavity and an effector arranged in the irradiation cavity. The irradiation cavity has an upper polar plate and a lower metal polar plate. A local area in the irradiation cavity around the effector is filled with a uniform medium, wherein the relative dielectric constant of the uniform medium is between theair and the relative dielectric constant of the effector. One of the upper polar plate and the lower metal polar plate has a pointed end formed by bending; and the pointed end is close to the uniformmedium and corresponds to the e focus position of the effector. On the basis of the field-intensity focusing mode, the slow transition of the relative dielectric constant of the medium and the local enhancement of the current at the pointed end of the metal are both considered, so that the focusing effect of the field inside the effector in the irradiation cavity is realized.

Description

technical field [0001] The invention relates to a device for realizing the internal field intensity focusing of non-metal effect objects in an irradiation cavity. Background technique [0002] The blood-brain barrier (BBB) ​​structure is one of the most complex and important barriers in the brain, composed of capillary and microvascular endothelial cells, pericytes, basement membrane and astrocytes It has a strict selection and permeability mechanism for various substances in the circulating blood, ensuring a high degree of stability in the brain environment to facilitate the functional activities of the central nervous system. However, while BBB prevents foreign bodies (including microorganisms, viruses, etc.) "EMP-induced BBB-disruption enhances drug delivery to glioma and increases treatment efficacy in rats"). Therefore, for diseases of the central nervous system, it is difficult to achieve effective drug absorption due to the existence of the BBB, which seriously rest...

Claims

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Application Information

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IPC IPC(8): A61N5/00
CPCA61N5/00
Inventor 朱湘琴陈昌华杜太焦胡龙蔡利兵郑奎松
Owner NORTHWEST INST OF NUCLEAR TECH
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