Compound sulfachloropyridazine and preparation method thereof

A technology of sulfachloropyridazine and compound sulfanilamide is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., which can solve problems such as poor bacteriostatic performance, and achieve strong bacteriostatic ability, convenient operation and process. simple effect

Active Publication Date: 2019-03-08
镇江威特药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Purpose of the invention: for the problems referred to above, one of purpose of the present invention is to provide a kind of compound recipe sulfachloropyridazine, to solve the technical problem of poor antibacterial performance

Method used

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  • Compound sulfachloropyridazine and preparation method thereof
  • Compound sulfachloropyridazine and preparation method thereof
  • Compound sulfachloropyridazine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound sulfachloropyridazine, comprising the following components: 70 g of sulfachloropyridazine, 3.5 g of omeprene, and 26.5 g of starch.

[0028] Wherein, the mass ratio of sulfachloropyridazine and omeprene is 20:1.

[0029] The preparation method of the compound sulfachloropyridazine is as follows: fully mix sulfachloropyridazine, omeprene and starch according to the formula quantity to make a powder to obtain the compound sulfachloropyridazine.

Embodiment 2

[0031] A compound sulfachloropyridazine comprises the following components: 60 g of sulfachloropyridazine, 6 g of omeprene, and 34 g of starch.

[0032] Wherein, the mass ratio of sulfachloropyridazine and omeprene is 10:1.

[0033] The preparation method of the compound sulfachloropyridazine is as follows: fully mix sulfachloropyridazine, omeprene and starch according to the formula quantity to make a powder to obtain the compound sulfachloropyridazine.

Embodiment 3

[0035] A compound sulfachloropyridazine comprises the following components: 30 g of sulfachloropyridazine sodium, 30 g of omeprelin, and 40 g of glucose.

[0036] Wherein, the mass ratio of sulfachloropyridazine sodium to omeprene is 1:1.

[0037] A preparation method of compound sulfachloropyridazine, comprising the following steps: fully mixing sulfachloropyridazine sodium, omeprene and glucose according to the formula quantity to prepare a powder to obtain compound sulfachloropyridazine.

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Abstract

The invention discloses compound sulfachloropyridazine. The compound sulfachloropyridazine is prepared from sulfachloropyridazine or salt thereof and ormetoprim, wherein the mass ratio of the sulfachloropyridazine or the salt thereof to the ormetoprim ranges from (20 to 1) to (1 to 1); the invention further discloses a preparation method of the compound sulfachloropyridazine; the preparation method comprises the following step: sufficiently mixing the sulfachloropyridazine or the salt thereof and the ormetoprim to prepare the compound sulfachloropyridazine. The compound sulfachloropyridazine has the advantages that the ormetoprim is added into the sulfachloropyridazine or the salt thereof, and the ormetoprim is used for inhibiting bacterial dihydrofolate reductase to interfere the synthesis of tetrahydrofolic acid, so as to inhibit the growth of bacteria; the ormetoprim has a relatively strong self bacterium-inhibiting capability, is combined with the sulfachloropyridazine or the saltthereof to have a stronger antibacterial synergistic effect and has a synergistic effect; the ormetoprim more easily penetrates through a tissue barrier and the compound sulfachloropyridazine more easily enters endometrium to express better medicinal performance.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound sulfachloropyridazine and a preparation method thereof. Background technique [0002] Sulfa drugs are commonly used drugs for the prevention and treatment of animal diseases, which inhibit the growth of bacteria by inhibiting dihydrofolate synthase. At present, sulfa drugs are often used in combination with sulfa synergists such as trimethoprim to enhance the bactericidal effect of sulfa drugs. Sulfa synergists interfere with the synthesis of tetrahydrofolate by inhibiting bacterial dihydrofolate reductase, thereby synergizing the efficacy of sulfa drugs. Trimethoprim is widely used as a traditional sulfa synergist, including compound preparations with sulfamethoxine sodium, sulfachlordazine sodium, sulfadiazine and other sulfa drugs. With the extensive use of sulfa drugs and trimethoprim, bacterial resistance to sulfa drugs began to appear, and trimethoprim itself...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/505A61P31/04A61P33/00
CPCA61K31/505A61K31/635A61P31/04A61P33/00A61K2300/00
Inventor 戴荣贵黄文江贺文庆
Owner 镇江威特药业有限责任公司
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