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A Method of Rat Femoral External Fixator with Variable Stiffness to Promote Secondary Fracture Healing

An external fixator and fixator technology, which is applied in the field of biomedical engineering, can solve the problems that the fracture end does not meet the comprehensive stress, it is difficult to clinically guide the fracture treatment, etc., and achieves the improvement of the fracture treatment level, safe and effective treatment measures, and recovery. The effect of joint function

Active Publication Date: 2021-04-30
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

Because the research method mostly chooses a single stress form, which does not conform to the comprehensive stress of the fracture end of the clinical patient, many research results are difficult to apply to the clinical guidance of fracture treatment

Method used

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  • A Method of Rat Femoral External Fixator with Variable Stiffness to Promote Secondary Fracture Healing
  • A Method of Rat Femoral External Fixator with Variable Stiffness to Promote Secondary Fracture Healing
  • A Method of Rat Femoral External Fixator with Variable Stiffness to Promote Secondary Fracture Healing

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Embodiment Construction

[0034] The method of the present invention will be specifically described below in conjunction with the accompanying drawings and embodiments.

[0035] 1 Materials and methods

[0036] 1.1 The rat femoral external fixator with variable stiffness consists of 4 steel pins (made by Orphfix in Italy), four crossbeams for fixing the steel pins and stiffness adjustment rods connecting the crossbeams. Steel needle diameter 1mm. The cross-beam material of the rat variable stent is a high-molecular polyethylene medical material, and its stiffness, elasticity, and toughness all meet the requirements of biomechanics, and it has the unique advantage of not blocking X-rays. The length, width, and height of the four crossbeams of the rat quantitative variable bracket are 10mm, 5.5mm, and 6mm, respectively, and are fixed by two titanium alloy miniature screws with a diameter of 2.6mm (the titanium alloy screws are purchased from Johnson & Johnson). The stiffness of the rat femoral external...

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Abstract

The invention relates to the field of biomedical engineering, in particular to a method for promoting second-stage healing of fractures with a variable-rigidity rat femoral external fixator. The technical scheme adopted in the present invention is: (1) 0 days to 7 days after the rat fracture model is made, which is the stem cell recruitment period, adjust the stiffness of the rat femoral external fixator with variable stiffness to 12.7N / mm~15N / mm; (2) 8 days to 21 days after the rat fracture model was made, which is the stem cell differentiation period, during which the rigidity of the fixator was increased to 25N / mm~30N / mm; (3) The rat fracture model was made From 22 days to 35 days, which is the osteogenesis period, adjust the rigidity of the fixator to 50N / mm~56.2N / mm. This method provides a scientific theoretical basis and safe and effective treatment measures for improving the level of fracture treatment and achieving the goal of fracture treatment.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a method for promoting second-stage healing of fractures with a variable-rigidity rat femoral external fixator. Background technique [0002] There are two types of fracture healing: Ⅰ healing and Ⅱ healing. Among them, phase II healing has a large number of calluses, which is an ideal form of fracture healing, and it is also a clinically desirable treatment result. For a long time, a large number of research results have proved that stress is one of the most important factors in regulating fracture healing by second intention, and the mechanism and method of stress regulating fracture healing have been discussed. Since the research method mostly chooses a single stress form, which does not conform to the comprehensive stress of the fracture end of the clinical patient, many research results are difficult to apply to the clinical guidance of fracture treatment. In the proc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61D7/00A61D1/00G01N21/84
CPCA61D1/00A61D7/00G01N21/84
Inventor 张俊忠曹慧
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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