Method for assisting determination of hematological stage of childhood acute lymphoblastic leukemia

A leukemia and hematology technology, applied in biochemical equipment and methods, microbiological measurement/testing, computer-aided medical procedures, etc., can solve the problems that the usefulness has not yet been concluded, MRD monitoring markers are insufficient, etc.
CN109477148APending Publication Date: 2019-03-15OTSUKA PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OTSUKA PHARM CO LTD
Publication Date
2019-03-15

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Abstract

Provided are a method for assisting the determination of hematological stage of childhood acute lymphoblastic leukemia (childhood ALL) and an extracorporeal diagnostic agent usable in the method. Themethod for assisting the determination of hematological stage of childhood ALL comprises: (1) a step for acquiring the mRNA quantity of Wilms' tumor gene 1 (WT1) in biological sample(s) comprising theperipheral blood and / or the bone marrow fluid of a subject; (2) a step for acquiring the mRNA quantity of GAPDH in the above sample(s); and (3) a step for calculating an index value necessary for assisting the determination on the basis of the ratio between the WT1 mRNA quantity and the GAPDH mRNA quantity that are acquired respectively in the above steps (1) and (2).
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Description

technical field

[0001] The invention relates to a method for assisting the judging of the hematology stage of children's acute lymphoblastic leukemia. Specifically, it relates to a method for discriminating whether a child subject suffering from or suspected of having acute lymphoblastic leukemia is in a non-remission phase or a remission phase of acute lymphoblastic leukemia. In addition, the present invention relates to an in vitro diagnostic drug that is effective for assisting in the judgment of the hematological stage of acute lymphocytic leukemia, in particular, assisting in the judgment of transition from the non-remission phase to the remission phase, and from Auxiliary judgment for transition from remission to non-remission, or monitoring of hematological stages of acute lymphoblastic leukemia. Background technique

[0002] The kit (WT1 mRNA measurement kit) for measuring the amount of WT1 mRNA (Wilms' tumor gene 1 messenger ribonucleic acid, Wilms' tumor-1 gene me...

Claims

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