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Preparation method of magnetic nano photosensitizer composite system

A magnetic nano-composite system technology, applied in the field of genetic engineering, can solve problems such as non-tissue specificity

Inactive Publication Date: 2019-03-19
SOUTHEAST UNIV
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  • Abstract
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Problems solved by technology

However, in these studies, bioluminescence as the energy source of PDT is not tissue-specific, and its main constraint is that, in order to meet the conditions of energy resonance transfer, the luciferase that produces bioluminescence usually needs to be compatible with the energy acceptor. Covalently bonded together, but not specifically expressed in tumor cells

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  • Preparation method of magnetic nano photosensitizer composite system
  • Preparation method of magnetic nano photosensitizer composite system
  • Preparation method of magnetic nano photosensitizer composite system

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Embodiment Construction

[0042] The present invention will be further specifically described below by way of examples.

[0043] Main steps of the present invention include:

[0044] (1) Fe 3 o 4 @SiO 2 Preparation of @Qdots / PS Composite Nanoparticles: Co-precipitation Method to Prepare Iron Tetroxide Magnetic Nanoparticles Fe 3 o 4 , coated with a thin layer of silicon dioxide on its surface to form Fe 3 o 4 @SiO 2 ; Select quantum dots (Qdots) with an emission wavelength of 630nm and a photosensitizer dihematoporphyrin ether (PS) with an absorption wavelength of 630nm, and assemble them on Fe through adsorption 3 o 4 @SiO 2 On the surface, the photosensitizer dihematoporphyrin ether was dissolved in saline to make 0.1mg / ml, mixed with CdTe colloidal solution (0.1mg / ml), and slowly dropped into Fe 3 o 4 @SiO 2 (0.1mg / ml) solution, pass N 2Stir the reaction at room temperature overnight, 1×10 6 rpm ultracentrifugation to precipitate Fe 3 o 4 @SiO 2 @Qdots / PS nanoparticles, resuspended ...

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Abstract

The invention relates to a preparation method of a magnetic nano photosensitizer composite system. The method includes preparing Fe3O4 magnetic nano particles; coating a thin layer of silicon dioxideon the surfaces of the Fe3O4 magnetic nano particles by using ethyl orthosilicate as a modifier; and assembling quantum dots CdTe and a photosensitizer on the surfaces by utilizing the adsorption effect of silicon dioxide boundary pore microspheres to obtain magnetic nano photosensitizer particles Fe3O4@SiO2@Qdots / PS. The method can utilize tumor cell specific bioluminescence as a light source, the photosensitizer is excited to generate active oxygen clusters, and electric energy can be converted into heat energy in an alternating electric field, so that the magnetic nano photosensitizer is anovel multifunctional photosensitizer.

Description

technical field [0001] The invention belongs to the field of genetic engineering, and in particular relates to a preparation method and application of a magnetic nanometer photosensitive composite system. Background technique [0002] Photodynamic therapy (PDT) uses a light source of a certain wavelength to irradiate the photosensitizer, and the excited photosensitizer reacts with oxygen molecules to generate reactive oxygen species (ROS) mainly composed of singlet oxygen. resulting in a toxic effect on cells. Photodynamic therapy is an effective, non-invasive means of tumor treatment. However, in the more than 30 years of its clinical application, photodynamic therapy has not been able to become the main means of tumor treatment (except for superficial skin cancer), only as a palliative treatment or an adjuvant to other treatment methods, mainly because of its therapeutic effect. Limitations and emerging adverse effects. Whether the laser is directly irradiated or the op...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0071A61P35/00A61K2300/00
Inventor 袁晨燕安艳丽张东生
Owner SOUTHEAST UNIV
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