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A kind of absorbable anti-adhesion material and film for its preparation after cardiac surgery

A post-surgical, anti-adhesion technology, applied in the field of medical materials and films prepared therefrom, can solve the problems of poor flexibility and stretch index, too fast in vivo degradation rate, uncontrollable mechanical properties, etc., and achieves flexible hand feel and good water permeability , no cytotoxic effect

Active Publication Date: 2020-02-07
北京百利康生化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These films still have the following deficiencies: poor flexibility and tensile index; uncontrollable mechanical properties, not easy to shape under the condition of water in the body; too fast degradation rate in vivo, which does not match the use requirements; film performance is not stable enough, and even light hypersensitivity reaction

Method used

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  • A kind of absorbable anti-adhesion material and film for its preparation after cardiac surgery
  • A kind of absorbable anti-adhesion material and film for its preparation after cardiac surgery
  • A kind of absorbable anti-adhesion material and film for its preparation after cardiac surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Select medium-viscosity chitosan with a viscosity of 0.25 Pa·s and a degree of deacetylation of 95%, dissolve chitosan in 15 wt% acetic acid solution, and prepare a chitosan solution with a weight percentage of 15 wt%. Take 45 kg of chitosan liquid; 5 kg of gelatin, 15 kg of glycerin, 10 kg of collagen, 5 kg of hyaluronic acid, and 10 kg of sodium carboxymethyl cellulose; react at 100°C for 55 hours, cool down to obtain chitosan sugar reaction solution. Dissolving 10 kg of silk fibroin in 40 kg of 25 wt% ethanol solution, filtering, centrifuging, and removing the insoluble part to obtain a silk fibroin stock solution.

[0032] With 15wt% acetic acid solution, the concentration of the mixed solution of chitosan reaction solution and silk fibroin stock solution is adjusted to 5wt%, filtered, and injected into the mould after leaving standstill for 10 hours for defoaming; The volume ratio is 1000:15 to make a coagulation solution, and then put the mold into the coagulatio...

Embodiment 2

[0040] Dissolve medium viscosity chitosan with a viscosity value of 0.65 Pa·s and chitosan with a deacetylation degree of 85% in 20 wt% acetic acid solution to form a chitosan solution with a weight percentage of 20 wt%. Select 45 kg of chitosan liquid, 10 kg of gelatin, 10 kg of glycerin, 10 kg of collagen, 10 kg of hyaluronic acid, and 5 kg of sodium carboxymethyl cellulose; react at 90°C for 85 hours, cool down, and obtain chitosan sugar reaction solution. Dissolving 10 kg of silk fibroin in 40 kg of 20 wt% ethanol solution, filtering, centrifuging, and removing the insoluble part to obtain a silk fibroin stock solution.

[0041] Use 20wt% acetic acid solution to adjust the concentration of the mixed solution of chitosan reaction solution and silk fibroin stock solution to 20wt%, filter, leave to stand for 5 hours after defoaming, inject mold; the sodium hydroxide of absolute ethanol, 15wt% concentration Make a coagulation solution at a volume ratio of 1000:15, then put th...

Embodiment 3

[0044] Choose medium-viscosity chitosan with a viscosity value of 0.35Pa·s, and a degree of deacetylation of 92%. Dissolve chitosan in 10wt% acetic acid solution to configure a chitosan solution with a weight percentage of 15wt%. Choose 45 kg of shell Polysaccharide liquid, 5 kg of gelatin, 25 kg of glycerin, 10 kg of collagen, 5 kg of hyaluronic acid, 5 kg of sodium carboxymethyl cellulose; react at 95°C for 70 hours, cool down to obtain chitosan reaction liquid. Dissolving 5 kg of silk fibroin in 15wt% ethanol solution, filtering, centrifuging, and removing the insoluble part to obtain the silk fibroin stock solution.

[0045] Use 10wt% acetic acid solution to adjust the concentration of the mixed solution of chitosan reaction solution and silk fibroin stock solution to 15wt%, filter, leave to stand for 15 hours after defoaming, inject mold; the sodium hydroxide of absolute ethanol, 10wt% concentration Make a coagulation solution at a volume ratio of 1000:20, then put the mo...

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Abstract

The invention discloses a post-operation absorbable anti-adhesion material for cardiac surgery and a film prepared from the material. The material is prepared from the following ingredients in parts by weight: 45 to 85 parts of chitosan, 5 to 25 parts of gelatin, 5 to 15 parts of glycerol, 5 to 20 parts of collagen and 5 to 20 parts of silk fibroin. A preparation method of an isolation film comprises the following steps of preparing 90 kg of 15-weight-percent chitosan mixed solution; preparing 50 kg of silk fibroin stock solution with the concentration being 10 to 25 percent; mixing the mixedsolution and the silk fibroin stock solution to the concentration being 10 to 20 weight percent by an acetic acid solution with the concentration being 2 to 15 weight percent; performing filtering; performing still standing for 5 to 24 hours; performing defoaming; after the defoaming, putting the materials into a baking oven being 40 to 70 DEG C for drying, thus obtaining the film. The anti-adhesion film prepared by the method is used for the cardiac surgery, has good biocompatibility, is absorbable and degradable, and can prevent the heart and peripheral tissue adhesion after the surgery, protect the heart function, and avoid secondary thoracotomy difficulty increase and occurrence of complications such as hemorrhea caused by adhesion.

Description

【Technical field】 [0001] The invention relates to a medical material and a film prepared therefrom, in particular to an absorbable anti-adhesion material used in heart surgery and a film prepared therefrom. 【Background technique】 [0002] Postoperative pericardial adhesions such as coronary artery grafting, various valve replacements and angioplasty, atrial defect repair, ventricular septal defect repair, right ventricular outflow tract dredging, aortic sinus aneurysm repair, etc. One of the complications we face, the risk is to increase the risk of secondary surgery and the difficulty of thoracotomy, so it is necessary to solve pericardial adhesion after cardiac surgery. The application of anti-adhesion technology in cardiac surgery is increasing day by day, and the application of anti-adhesion film is increasing It has received the attention of various heart centers at home and abroad. [0003] At present, the common anti-adhesion films after abdominal surgery on the mark...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/04
CPCA61L31/042A61L31/044A61L31/045A61L31/047A61L31/14A61L31/148C08L5/08C08L89/00
Inventor 王国强施虹
Owner 北京百利康生化有限公司
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