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Aureomycin microcapsule particles used for oral administration of ruminants and preparation method thereof

A ruminant, chlortetracycline technology, applied in microcapsules, medical preparations with inactive ingredients, capsule delivery, etc., can solve problems such as digestive disorders, animals do not ruminate, and achieve fewer processes, low production energy consumption, and flow rate. Good dispersion effect

Active Publication Date: 2019-03-29
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The production process is simple, and it solves the problems that the existing medicines are easily caused by the oral administration of the existing drugs, and the animals do not ruminate and have digestive disorders.

Method used

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  • Aureomycin microcapsule particles used for oral administration of ruminants and preparation method thereof
  • Aureomycin microcapsule particles used for oral administration of ruminants and preparation method thereof
  • Aureomycin microcapsule particles used for oral administration of ruminants and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 prepares aureomycin microcapsule preparation

[0048] The preparation steps are as follows:

[0049] S1. Weigh each auxiliary material according to the following formula ratio (based on the total mass as 100g):

[0050] Chlortetracycline premix 44%;

[0051] Hydrogenated oil 56%;

[0052] Heat to melt at 90°C and mix well;

[0053] S2. Add the aureomycin premix to the auxiliary material obtained in S1, and stir evenly to obtain a mixed material;

[0054] S3. Cool the mixed material obtained in S2 to 70-85°C, and carry out the stage of fluidized bed spray granulation and spheroidization. The temperature of the fluidized air in the granulation and spheroidization stage is 5°C. The linear velocity is 40 m / s;

[0055] S4. Cool, sieve, and collect to obtain 10% aureomycin microcapsules, which are black spherical particles with a particle size of 250-850 μm.

Embodiment 2

[0056] Embodiment 2 prepares aureomycin microcapsule preparation

[0057] S1. Weigh each auxiliary material according to the following formula ratio (based on the total mass as 100g):

[0058] Chlortetracycline premix 44%;

[0059] Glyceryl monostearate 56%;

[0060] Heat to melt at 90°C and mix well;

[0061] S2. Add the aureomycin premix to the auxiliary material obtained in S1, and stir evenly to obtain a mixed material;

[0062] S3. Cool the mixed material obtained in S2 to 70-85°C, and carry out the stage of fluidized bed spray granulation and spheroidization. The temperature of the fluidized air in the granulation and spheroidization stage is 5°C. The linear velocity is 40 m / s;

[0063] S4. Cool, sieve, and collect to obtain 10% aureomycin microcapsules, which are black spherical particles with a particle size of 250-850 μm.

Embodiment 3

[0064] Embodiment 3 prepares aureomycin microcapsule preparation

[0065] S1. Weigh each auxiliary material according to the following formula ratio (based on the total mass as 100g):

[0066] Chlortetracycline premix 44%;

[0067] PEG400056%;

[0068] Heat to melt at 90°C and mix well;

[0069] S2. Add the aureomycin premix to the auxiliary material obtained in S1, and stir evenly to obtain a mixed material;

[0070] S3. Cool the mixed material obtained in S2 to 70-85°C, and carry out the stage of fluidized bed spray granulation and spheroidization. The temperature of the fluidized air in the granulation and spheroidization stage is 5°C. The linear velocity is 45 m / s;

[0071] S4. Cool, sieve, and collect to obtain 10% aureomycin microcapsules, which are black spherical particles with a particle size of 250-850 μm.

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Abstract

The invention discloses aureomycin microcapsule particles used for oral administration of ruminants and a preparation method thereof. The aureomycin microcapsule particles are prepared from 30-50 parts of a aureomycin premix and 50-70 parts of auxiliary materials in parts by mass. The auxiliary materials are prepared by compounding hydrophobic capsule materials and / or hydrophilic capsule materials. The preparation method comprises the following steps: heating and melting of capsule materials, uniform mixing, addition of the aureomycin premix, uniform stirring, fluidized bed spraying granulation and balling with a scientific process, cooling, sieving, and collecting. The obtained aureomycin microcapsule particles can be effectively released after passing through rumen and can be rapidly disintegrated and dissolved in reticulum and abomasum, and medicines can be fully absorbed by animals in small intestines after being taken by animals so as to achieve systemic effect and to improve oralbioavailability of aureomycin. The particles can obviously reduce the abortion rate caused by campylobacter fetus ewes during pregnancy clinically, can be conveniently mixed and fed for administration, and are convenient for administration. In addition, the preparation process is simple, low in cost, and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine. More specifically, it relates to a chlortetracycline microcapsule particle for oral administration to ruminants and a preparation method thereof. Background technique [0002] Chlortetracycline (CTC), also known as chloramphenicol, is a tetracycline broad-spectrum antibiotic developed by the American cyanamide company in 1949. It is effective against gram-positive bacteria, negative bacteria, rickettsia and large viruses. Broad suppression capability. Adding chlortetracycline to daily feed can effectively prevent bacterial enteritis, bacterial pneumonia and abortion rate caused by Campylobacter in breeding ewe embryos, and can also effectively improve the daily gain and feed conversion efficiency of livestock and poultry. In recent years, the incidence of diseases in ruminants (sheep, dairy cows, beef cattle, deer, etc.) is relatively high, especially in calves and lambs, such as th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/44A61K47/14A61K47/10A61K31/65A61P31/04
CPCA61K9/5015A61K9/5031A61K31/65A61P31/04
Inventor 黄显会胡浪李国基
Owner SOUTH CHINA AGRI UNIV
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