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Application of trpv5 gene snp site in detection of susceptibility to heavy metal poisoning

A heavy metal, susceptibility technology, applied in the field of biomedical molecular detection, to achieve the effect of reducing manual operations, avoiding probe hybridization, and improving economic and social benefits

Active Publication Date: 2022-05-27
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Currently, no studies have shown that TRPV5 gene polymorphisms are associated with susceptibility to heavy metal (such as lead) poisoning

Method used

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  • Application of trpv5 gene snp site in detection of susceptibility to heavy metal poisoning
  • Application of trpv5 gene snp site in detection of susceptibility to heavy metal poisoning
  • Application of trpv5 gene snp site in detection of susceptibility to heavy metal poisoning

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Embodiment 1

[0056] Example 1. Two newly discovered SNP sites on the TRPV5 gene are associated with susceptibility to heavy metal (lead) poisoning (case-control analysis)

[0057] 1. Taking 1,301 Chinese Han workers who have been exposed to lead-contaminated working environments for a long time (more than 2 years) as the research object, according to the diagnostic criteria of GBZ 37-2002 occupational chronic lead poisoning, the population with blood lead ≥ 400 μg / L is regarded as high blood lead. In the blood lead group (ie the lead poisoning susceptible group, the case group), the people with blood lead 0.05).

[0058] The above-mentioned blood lead determination was carried out by anodic stripping voltammetry using a 3010B blood lead analyzer from ESA Company in the United States to determine the lead content in blood.

[0059] 2. The genotypes of the SNP loci g.103 (C>T) and g.654 (G>A) of the above-mentioned high blood lead group (lead poisoning susceptible group) and low blood lead g...

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Abstract

The application discloses the application of a TRPV5 gene SNP site in detecting susceptibility to heavy metal poisoning. The SNP site is G>A at the 654th nucleotide of the TRPV5 gene, and the sequence of the TRPV5 gene is shown in SEQ ID No.10. The difference between G and A of the SNP site between the high blood lead group and the low blood lead group is extremely significant, wherein, G is a lead poisoning susceptibility allele or a lead poisoning high risk allele, and A is a non-lead poisoning Susceptibility allele or lead poisoning low risk allele. Therefore, by detecting the base type of this site and judging the genotype of this site, it can be used to detect the susceptibility or risk of heavy metal poisoning (such as lead) poisoning, screen patients with heavy metal poisoning, identify or assist in the identification of heavy metal poisoning susceptibility genes, Detection of single nucleotide polymorphisms associated with heavy metal toxicity or metabolism. The applications and products provided by the invention are of great value in the identification of susceptible groups to heavy metal poisoning, thereby reasonably preventing heavy metal poisoning.

Description

technical field [0001] The invention belongs to the technical field of biomedical molecular detection, in particular to the application of a TRPV5 gene SNP site in the detection of susceptibility to heavy metal poisoning. Background technique [0002] The original meaning of heavy metals refers to metals with a specific gravity greater than 5 (generally, metals with a density greater than 4.5 grams per cubic centimeter), including gold, silver, copper, iron, mercury, lead, cadmium, etc. Heavy metals accumulate in the human body to a certain extent. Can cause chronic poisoning. In terms of environmental pollution, heavy metals mainly refer to heavy elements with significant biological toxicity such as mercury (mercury), cadmium, lead, chromium and metalloid arsenic. Heavy metals are very difficult to be biodegraded, on the contrary, they can be enriched thousands of times under the bio-magnification of the food chain, and finally enter the human body. Heavy metals can inter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 叶秀峰刘文兰徐迹刘瑾许蕴余志英陈光福
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
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