Dedicated dispersion liquid for preparing high-resolution chromosome for karyotyping analysis

A technology of karyotype analysis and chromosome, which is applied in the biological field, can solve the problems of increased separation ratio and difficulty in observing the detailed banding of chromosomes, and achieve the effect of improving quality and spreading and dispersing effect
CN109540644AActive Publication Date: 2019-03-29BEIJING INST OF HUMAN GENETICS & REPRODUCTION MEDICINE LTD CHINA +2
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INST OF HUMAN GENETICS & REPRODUCTION MEDICINE LTD CHINA
Publication Date
2019-03-29

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Abstract

The invention relates to a dedicated dispersion liquid for preparing high-resolution chromosome for karyotyping analysis. The dedicated dispersion liquid for preparing high-resolution chromosome for karyotyping analysis is characterized by comprising the following components: 0.05-1mmol / L of Tris-HCL in pH of 7.5 to 10.0 and 2-8g / L of KCl, wherein the solvent is tri-distilled water. The dedicateddispersion liquid for preparing high-resolution chromosome for karyotyping analysis disclosed by the invention has good spread dispersion effect on the lymphocyte chromosome, the intersection and overlapping number between the chromosomes are reduced for the high-resolution and ultra-high-resolution karyotype analysis, and the quality for analyzing the karyotype is greatly improved.
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Description

technical field

[0001] The invention belongs to the field of biotechnology and relates to the special preparation of high-resolution chromosome dispersion liquid for karyotype analysis. Background technique

[0002] Chromosomes are the carriers of genes. There are 23 pairs of 46 chromosomes in normal human cells, of which 22 pairs and 44 are autosomes, and the other pair is 2 sex chromosomes. Chromosomes may undergo quantitative and structural changes, resulting in various genetic defects, congenital genetic diseases, embryo suspension and spontaneous abortion, tumors, etc. Diseases caused by chromosomal abnormalities are generally called chromosomal diseases.

[0003] Chromosomal detection is currently mostly used in clinical practice such as reproduction, obstetrics and gynecology, newborns, blood diseases, tumors and other specialties. Although the method is relatively simple, it is still the gold standard for prenatal diagnosis by using the chromosome banding technique...

Claims

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