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Traditional Chinese medicine compound used for treating parkinson's disease and preparation method and application thereof

A technology for Parkinson's disease and composition, which is applied in the field of traditional Chinese medicine composition for treating Parkinson's disease and its preparation, can solve the problems of weakening curative effect and increasing toxic and side effects, and achieve the effect of effectively treating Parkinson's disease

Active Publication Date: 2019-04-05
TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the current treatment of PD is still in an embarrassing situation. Many treatments, including drugs, can only relieve symptoms and delay the course of the disease, but cannot play a role in nerve repair and neuroprotection to block or reverse the course of the disease. After application, curative effect weakens and side effects increase

Method used

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  • Traditional Chinese medicine compound used for treating parkinson's disease and preparation method and application thereof
  • Traditional Chinese medicine compound used for treating parkinson's disease and preparation method and application thereof
  • Traditional Chinese medicine compound used for treating parkinson's disease and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Preparation of Chinese Medicine Composition

[0033] Ingredients by weight: 120 parts of Polygonum multiflorum; 100 parts of Prunella vulgaris; 80 parts of Shouwu vine; 60 parts of Danshen; 80 parts of Jujube seed; 60 parts of Scrophulariaceae; 80 parts of white peony; 40 parts of Bupleurum; 30 servings of licorice.

[0034] Preparation method: pulverize salvia miltiorrhiza, white peony root, and Bupleurum sylvestris into fine powder, sieving; add water and decoct the remaining seven flavors twice, 2 hours each time, filter in sections, combine the filtrate, and concentrate the filtrate to a relative density of 1.25 to 1.28 Clear ointment; mix the above subdivided and clear ointment, and obtain the traditional Chinese medicine composition after drying.

Embodiment 2

[0035] Example 2 Preparation of Chinese Medicine Composition

[0036] Ingredients by weight: 120 parts of Polygonum multiflorum; 100 parts of Prunella vulgaris; 80 parts of Shouwu vine; 60 parts of Danshen; 80 parts of Jujube seed; 60 parts of Scrophulariaceae; 80 parts of white peony; 40 parts of Bupleurum; 30 servings of licorice.

[0037] Preparation:

[0038] (1) The raw materials of traditional Chinese medicine are heated and refluxed with ethanol with a volume fraction of 40% for 2 times, each extraction is 1.5h, and the two extracts are combined to obtain an alcohol extract after being concentrated to no alcohol; the total weight of the raw materials of traditional Chinese medicine is The dosage ratio of ethanol aqueous solution is 1g:10mL;

[0039] (2) Put the alcohol extract on the D101 non-polar macroporous resin chromatography column, first eluting with 3 times the column volume of 8% ethanol aqueous solution to remove impurities; then use 5 times the volume fraction of th...

experiment example 2

[0071] Experimental Example 2 The effect of traditional Chinese medicine composition on dopamine and its metabolites in mouse striatum

[0072] With reference to the grouping and method of Experimental Example 1, C57BL / 6 mice were given continuous administration for 14 days. After 14 days of administration, the head was decapitated and the brain striatum was taken. The dopamine (DA) and its content in the mouse striatum were determined by HPLC. The content of the metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HAV) are shown in Table 2.

[0073] Table 2. Effect of Chinese medicine composition on dopamine and its metabolites in mouse striatum

[0074]

[0075] Compared with the normal group, **P<0.01,***P<0.001; compared with the model group, ##P<0.01, ###P<0.01

[0076] It can be seen from the experimental data in Table 2 that the content of dopamine and its metabolites dihydroxyphenylacetic acid and homovanillic acid in the striatum of the Parkinson’s disease mo...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine compound used for treating parkinson's disease and a preparation method and application thereof. The traditional Chinese medicine compound used for treating parkinson's disease is prepared from the following traditional Chinese medicines in parts by weight: 100-150 parts of radix polygonum multiflorum preparata, 80-120 parts of prunellae spica, 70-90 parts of vine of multiflower knotweed, 50-70 parts of radix salviae miltiorrhizae, 70-90 parts of semen ziziphi spinosae, 50-70 parts of radix scrophulariae, 70-90 parts of radix paeoniae alba, 30-50 parts of radix bupleuri, 50-70 parts of cortex albiziae and 20-40 parts of radix glycyrrhizae. The traditionalChinese medicine compound has an efficient effect of treating parkinson's disease, has low toxicity at the same time, and can be used for preparing an efficient low-toxic medicine for resisting parkinson's disease.

Description

Technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating Parkinson's disease, and a preparation method and application thereof. Background technique [0002] Parkinson’s disease (PD), also known as tremor palsy, is the second most common degenerative disease of the central nervous system, and its incidence continues to increase as the population ages. The pathogenesis of PD is complicated. Due to a variety of factors, the dopamine neurons located in the substantia nigra of the brain have irreversible degenerative lesions. At present, the clinical "symptomatic treatment" that mainly supplements the content of dopamine in the brain treats the symptoms but not the root cause, and there is still a long way to go to study the pathogenesis of PD and anti-PD drugs. Based on the theory of TCM syndrome differentiation and treatment combined with many years of clini...

Claims

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Application Information

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IPC IPC(8): A61K36/808A61P25/16
CPCA61K36/233A61K36/48A61K36/484A61K36/536A61K36/537A61K36/65A61K36/704A61K36/71A61K36/725A61K36/808A61K2236/331A61K2236/39A61K2236/51A61P25/16A61K2300/00
Inventor 黎赛彭康张鑫文小敏盛小燕罗晓君王春燕马国鲁
Owner TCM INTEGRATED HOSPITAL OF SOUTHERN MEDICAL UNIV
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