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Compositions and methods for modulating gastrointestinal microflora in a canine

A technology of microorganisms and compositions, applied in the field of compositions of gastrointestinal microflora, can solve problems such as unclear pets

Pending Publication Date: 2019-04-16
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is unclear whether the same is true for pets

Method used

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  • Compositions and methods for modulating gastrointestinal microflora in a canine
  • Compositions and methods for modulating gastrointestinal microflora in a canine
  • Compositions and methods for modulating gastrointestinal microflora in a canine

Examples

Experimental program
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Embodiment approach

[0026] In one aspect of the present disclosure, a method of modulating the gastrointestinal microflora of a canine can comprise administering to the canine a Fiber pet food composition. Generally, the canine canine may have a ratio of Bacteroidetes to Firmicutes (B / F) of less than 0.8 following administration.

[0027] In another aspect, a method of treating diabetes, obesity, inflammatory disease, cardiovascular disease, metabolic disorder, musculoskeletal disorder, or cancer in a canine can comprise dividing the phylum Bacteroidetes to the phylum Firmicutes (B / F) The ratio is adjusted to be lower than 0.8

[0028]In addition, the methods of the present disclosure may include identifying different populations of canines according to desired treatment. In one embodiment, the method may further comprise identifying a canine in need of B / F ratio adjustment. Canines in need thereof may include canines with diabetes, obesity, inflammatory disease, cardiovascular disease, metab...

Embodiment 1

[0049] Example 1 - Canine microbiota studies

[0050] 32 Beagles and 32 Labradors were selected, half obese / overweight and half lean / normal. All dogs were fed a basal diet for 4 weeks (Phase 1). Dogs were randomized into two dietary groups according to age, sex and body fat (Table 1 - Study Design). Dogs were fed diet A (HPLC) or diet B (LPHC) for an additional 4 weeks (Phase 2). Fecal samples were collected at the end of each period. Diets are provided in Table 2.

[0051] Table 1

[0052]

[0053] Basic diet: Chicken and rice; Diet A: high protein, low carbohydrate; Diet B: high carbohydrate, low protein

[0054] Table 2

[0055] diet

protein (dry weight%)

Fat (dry weight%)

carbohydrate (dry weight%)

crude fiber (dry weight%)

Base

27.42

16.62

39.48

1.51

A

49.42

16.9

15.4

4.23

B

24.95

16

42.03

3.43

[0056] The 16S rRNA gene ...

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Abstract

The present invention relates to methods and compositions for modulating gastrointestinal microflora of a canine. In one embodiment, a method of modulating gastrointestinal microflora in a canine cancomprise administering to the canine a pet food composition comprising from about 25% to about 60% protein, from about 5% to about 30% carbohydrates, fat, and fiber; where after administration, the Bacteroidetes to Firmicutes (B / F) ratio of the canine is less than 0.8.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Application No. 62 / 382,923, filed September 2, 2016, the disclosure of which is incorporated herein by reference. Background technique [0003] In the United States, more than 50 percent of pets are overweight or obese. Health risks associated with excess body weight include diabetes, cardiovascular disease, metabolic disorders, musculoskeletal disorders, cancer, and shorter life expectancy. [0004] A large number of microorganisms or groups of microorganisms colonize the body surfaces and in the gastrointestinal (GI) tract of their hosts, forming a symbiotic relationship. The gut microbiota plays important roles in its host, including the regulation of nutrient absorption, energy homeostasis (including fat storage, lipogenesis, and fatty acid oxidation), and immune system development. Thus, dysbiosis between the gut microbiota and its host is associated with obesity ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K10/16A23K20/147A23K50/40
CPCA23K10/18A23K50/40A23K10/16A23K20/147A23K20/158A23K20/10A61K35/741A61K2035/115
Inventor Q·李
Owner SOC DES PROD NESTLE SA
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