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A kind of pharmaceutical composition for treating constipation and its preparation method and application

A technology for treating constipation and composition, applied in the directions of drug combination, pharmaceutical formula, medical raw materials derived from arthropods, etc. Peristalsis, promote gastrointestinal motility, avoid inactivation effect

Active Publication Date: 2021-09-17
尹芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor resistance of probiotics to low pH values, when taken orally, probiotics are not resistant to gastric acid and are easily inactivated, and the number of viable bacteria will also drop significantly.

Method used

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  • A kind of pharmaceutical composition for treating constipation and its preparation method and application
  • A kind of pharmaceutical composition for treating constipation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A pharmaceutical composition for treating constipation, which is made of the following raw materials in parts by weight: 3 parts of psyllium seed polysaccharide, 8 parts of bee pollen, 2 parts of probiotic agent, 1 part of konjac glucomannan, sodium alginate 1 part, calcium chloride 1 part.

[0022] Wherein, the probiotic bacterial agent is formed by mixing Lactobacillus bulgaricus, Bifidobacterium and Streptococcus thermophilus with a weight ratio of 0.7:0.7:0.5.

[0023] A preparation method of a pharmaceutical composition for treating constipation, comprising the following steps:

[0024] (1) Take sodium alginate, add deionized water at 20°C, stir fully, and configure a sodium alginate solution with a concentration of 0.8%; take konjac glucomannan and add deionized water at 55°C, stir fully, and configure A konjac glucomannan solution with a concentration of 0.6%; the obtained konjac glucomannan solution is mixed with a sodium alginate solution, heated in a water ba...

Embodiment 2

[0028] A pharmaceutical composition for treating constipation, which is made of the following raw materials in parts by weight: 4 parts of plantago polysaccharide, 10 parts of bee pollen, 4 parts of probiotic agent, 2 parts of konjac glucomannan, sodium alginate 2 parts, calcium chloride 2 parts.

[0029] Among them, the probiotic bacterial agent is formed by mixing Lactobacillus bulgaricus, Bifidobacterium and Streptococcus thermophilus at a weight ratio of 1:1.2:1.

[0030] A preparation method of a pharmaceutical composition for treating constipation, comprising the following steps:

[0031] (1) Take sodium alginate, add deionized water at 30°C, stir fully, and configure a sodium alginate solution with a concentration of 1%; take konjac glucomannan and add deionized water at 65°C, stir fully, and configure A konjac glucomannan solution with a concentration of 0.8%; the resulting konjac glucomannan solution is mixed with a sodium alginate solution, heated in a water bath at...

Embodiment 3

[0035] A pharmaceutical composition for treating constipation, which is made of the following raw materials in parts by weight: 3 parts of plantago polysaccharide, 9 parts of bee pollen, 2 parts of probiotic agent, 1 part of konjac glucomannan, sodium alginate 1 part, calcium chloride 2 parts.

[0036] Among them, the probiotic bacterial agent is formed by mixing Lactobacillus bulgaricus, Bifidobacterium and Streptococcus thermophilus with a weight ratio of 0.8:1:0.8.

[0037] A preparation method of a pharmaceutical composition for treating constipation, comprising the following steps:

[0038] (1) Take sodium alginate, add deionized water at 25°C, stir fully, and configure a sodium alginate solution with a concentration of 0.9%; take konjac glucomannan and add deionized water at 60°C, stir fully, and configure Concentration is 0.7% konjac glucomannan solution; the obtained konjac glucomannan solution is mixed with sodium alginate solution, heated in a water bath at a heatin...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating constipation, which is prepared from the following raw materials in parts by weight: 3-4 parts of plantago polysaccharide, 8-10 parts of bee pollen, 2-4 parts of probiotic agent, konjac Glucomannan 1-2 parts, sodium alginate 1-2 parts, calcium chloride 1-2 parts. On the one hand, the konjac glucomannan added in the present invention can promote intestinal peristalsis; Sugar and sodium alginate are compounded to embed probiotics, which can avoid the inactivation of probiotics in the stomach and achieve the effect of probiotics colonizing the intestinal tract; in addition, plantago polysaccharides, bee pollen, and probiotic bacterial agents in the present invention , Konjac glucomannan cooperate with each other to soften the stool, promote gastrointestinal motility, restore the balance of intestinal flora, and achieve the effect of treating constipation from the root.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a pharmaceutical composition for treating constipation, a preparation method and application thereof. Background technique [0002] Constipation is a common digestive system disease in clinical practice, and it is a gastrointestinal functional abnormality caused by multiple factors. Generally, there are more women than men, and more elderly people than young adults. In recent years, with the acceleration of the pace of life in China, bad postures such as long-term sitting, coupled with changes in dietary structure and bad living habits such as staying up late, the incidence of constipation is on the rise. Long-term constipation can not only cause hemorrhoids, induce cardiovascular and cerebrovascular diseases, and increase the risk of colon cancer, but also cause patients to have bad emotions such as irritability, depression, and anxiety. [0003] At present, the commonly used...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/00A61K35/747A61P1/10A61K35/745A61K35/744A61K35/741A61K35/64A61K33/14A61K31/736A61K31/734A61K31/715
Inventor 尹芳
Owner 尹芳
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