Synthesis method of 2-bromo-2-(2-fluoro-3-methoxyphenyl)ethyl acetate
A technology of methoxyphenyl and ethyl acetate, which is applied in the synthesis field of synthetic methods, can solve the problems of lengthy reaction route and low total reaction yield, and achieve low reaction energy consumption, low total yield and short preparation cycle Effect
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Embodiment 1
[0036] A kind of synthetic method of 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate, synthetic route is as follows:
[0037]
[0038] The synthetic method of above-mentioned 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate comprises the following steps:
[0039] One, the preparation of formula VI compound:
[0040] (1) 1.0 g, 1 equiv. of the compound of formula II was dissolved in 5 mL of diethyl ether in a constant pressure dropping funnel to prepare a diethyl ether solution of the compound of formula II for subsequent use;
[0041] Based on the compound of formula II, 1 equiv. of ethyl chloroacetate was dissolved in 3 mL of diethyl ether in a constant pressure dropping funnel to prepare a diethyl ether solution of ethyl chloroacetate for subsequent use;
[0042] (2) In terms of the compound of formula II, add 1.2 equiv. of n-butyllithium ether solution into the reactor, after cooling to -78°C, add 1.2 equiv. of TMEDA, stir and disperse, and add the The ether solut...
Embodiment 2
[0047] A kind of synthetic method of 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate, synthetic route is as follows:
[0048]
[0049] The synthetic method of above-mentioned 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate comprises the following steps:
[0050] One, the preparation of formula VI compound:
[0051] (1) 0.5 g, 1 equiv. of the compound of formula II was dissolved in 2.5 mL of diethyl ether in a constant pressure dropping funnel to prepare a diethyl ether solution of the compound of formula II for subsequent use;
[0052] Based on the compound of formula II, 1.1 equiv. of ethyl chloroacetate was dissolved in 1 mL of diethyl ether in a constant pressure dropping funnel to prepare a diethyl ether solution of ethyl chloroacetate for subsequent use;
[0053](2) In terms of the compound of formula II, add 1.1 equiv. of n-butyllithium ether solution into the reactor, cool to -85°C, add 1.1 equiv. of TMEDA, stir and disperse, and add The ether solution of Com...
Embodiment 3
[0058] A kind of synthetic method of 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate, synthetic route is as follows:
[0059]
[0060] The synthetic method of above-mentioned 2-bromo-2-(2-fluoro-3-methoxyphenyl) ethyl acetate comprises the following steps:
[0061] One, the preparation of formula VI compound:
[0062] (1) Dissolve 1.5 g, 1 equiv. of the compound of formula II in 15 mL of diethyl ether in a constant pressure dropping funnel to prepare a diethyl ether solution of the compound of formula II for subsequent use;
[0063] Based on the compound of formula II, 1.4 equiv. of ethyl chloroacetate was dissolved in 3 mL of ether in a constant pressure dropping funnel to prepare an ether solution of ethyl chloroacetate for subsequent use;
[0064] (2) Based on the compound of formula II, add 1.4 equiv. of n-butyllithium ether solution into the reactor, cool to -75°C, add 1.4 equiv. of TMEDA, stir and disperse, and add The ether solution of Compound II was added drop...
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