A flow chamber for simulating the flow environment behind a stent

Abstract

The present invention is a flow chamber for simulating the flow environment behind a support, which is characterized in that it includes an external screw rod, a sliding chamber is provided in the middle of the external screw rod, and a sliding rod is provided for rotation in the sliding chamber, and one end of the sliding rod There is a bracket protrusion, and the end of the outer screw rod close to the bracket protrusion is provided with a flow chamber, a groove is arranged in the middle of the flow chamber, a glass slide is arranged in the groove, and the slide bar passes through the A slide chamber is located within the flow chamber. The invention realizes the in vitro simulation of the blood flow environment after the stent is implanted in the blood vessel of the host, and provides the mechanical stimulation of the blood flow disturbance for the cultured cells at the bottom of the flow chamber. In this invention, the adjustable height of the lumen and the adjustable height of the stent wire protrusion make the flow chamber more flexible to simulate various mechanical environments after the stent is inserted into the host blood vessel; through the quantitative observation at the bottom of the flow chamber, it is relatively easy to culture cells in this mechanical environment. Real biological response, thus providing a new tool for studying adverse phenomena such as restenosis and thrombosis after stenting.

Description

technical field [0001] The invention relates to a flow chamber for simulating the flow environment behind a stent, which is a biomedical experimental device, in particular to a flow chamber for biological fluid experiments. Background technique [0002] Interventional stenting is a very common and highly effective treatment for occlusive atherosclerotic conditions. Although vascular stents have been greatly developed in terms of their configuration, materials, placement process, and postoperative antithrombotic drug therapy, the high incidence of postoperative intravascular restenosis and late thrombosis still affects the development of vascular stents. with its therapeutic effect. Studies have found that there is a close relationship between changes in the hemodynamic environment and the occurrence of adverse events (restenosis and thrombosis, etc.) during stenting. [0003] The flow chamber is a very effective tool to simulate the flow environment in vivo, but the existi...

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