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Method and system for preparing medicinal liposomes

A liposome and drug technology, applied in liposome delivery, methods of granulating raw materials, pharmaceutical formulations, etc., can solve liposome multiple embedding and affect liposome embedding effect and embedding rate , agglomeration of core material particles, etc.

Active Publication Date: 2019-05-07
塔尔普(北京)制药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, it is easy to cause the aggregation of core material particles and the repeated embedding of liposomes in the process of producing liposomes, which affects the embedding effect and embedding rate of liposomes.

Method used

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  • Method and system for preparing medicinal liposomes
  • Method and system for preparing medicinal liposomes
  • Method and system for preparing medicinal liposomes

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Embodiment Construction

[0023] Embodiments of the present invention are described in detail below, examples of which are shown in the drawings, wherein the same or similar reference numerals designate the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the figures are exemplary only for explaining the present invention and should not be construed as limiting the present invention.

[0024] Such as figure 1 Shown, the application provides a kind of preparation system of drug liposome, comprising: granulation kettle 19, the bottom of granulation kettle 19 is connected with the piping system that transports the supercritical carbon dioxide that dissolves wall material solution, granulation kettle 19 The upper part of the tube is connected with the pipeline system for transporting the supercritical carbon dioxide dissolved with the core drug.

[0025] Specifically, the pipeline system for transporting supercritical car...

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Abstract

The invention relates to the field of medicinal preparations, and especially relates to a method for preparing medicinal liposomes. The method includes the following steps: adjusting liquid carbon dioxide to a supercritical state; dissolving supercritical carbon dioxide in one pipeline with a core material drug, dissolving the supercritical carbon dioxide in the other pipeline with a wall materialsolution, and making the temperature of the supercritical carbon dioxide dissolved with the wall material solution being higher than that of the supercritical carbon dioxide dissolved with the core material drug; introducing the supercritical carbon dioxide dissolved with the core material drug after temperature adjusting into a granulation kettle from the upper part, introducing the supercritical carbon dioxide dissolved with the wall material solution into the granulation kettle from the lower part, and performing liposome granulation, wherein the pressure of the supercritical carbon dioxide dissolved with the core material drug and the pressure of the supercritical carbon dioxide dissolved with the wall material solution are greater than that in the granulation kettle; and collecting encapsulated liposomes. The method reduces the agglomeration of core material particles and the probability of the multiple embedding of the liposomes, and enhance the encapsulation rates of the liposomes.

Description

technical field [0001] The present application relates to the field of pharmaceutical preparations, in particular to a method and system for preparing pharmaceutical liposomes. Background technique [0002] Liposome is an artificial membrane. When amphiphilic molecules (such as phospholipids and sphingolipids) are dispersed in the water phase, the hydrophobic tails of the molecules tend to gather together to avoid the water phase, while the hydrophilic heads of the molecules are exposed to the water. Phase, the formation of closed vesicles with a bilayer structure. Liposomes can be used for transgenes or drugs, and liposome drugs used for drugs refer to microvesicles formed by encapsulating drugs in lipid bilayers. Specifically, liposome drugs use the feature that liposomes can fuse with cell membranes to deliver drugs into cells. [0003] In the prior art, the method for producing liposomes is generally to feed the configured emulsion into a supercritical kettle according...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K47/36A61K47/24A61K47/10A61K45/00B01J2/00
Inventor 胡勇刚冯涛
Owner 塔尔普(北京)制药技术有限公司
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